捻转血矛线虫的耐药性及其干预途径研究进展  

Progress in the Study of Drug Resistance and Its Reversal in Haemonchus contortus

作　　者：李案本 符娜娜 罗晓平 李军燕 刘阳[1] LI Anben;FU Nana;LUO Xiaoping;LI Junyan;LIU Yang(College of Life Science,Ningxia University/Key Laboratory of Conservation and Utilization of Western Characteristic Resources,Ministry of Education,Yinchuan 750021,China;Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences,Hohhot 010031,China)

机构地区：[1]宁夏大学生命科学学院/西部特色资源保护与利用教育部重点实验室,银川750021 [2]内蒙古自治区农牧业科学院,呼和浩特010031

出　　处：《畜牧兽医学报》2025年第2期523-533,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：宁夏自然科学基金项目(2024AAC03115);宁夏回族自治区重点研发计划(引才专项)(2021BEB04025);内蒙古自然科学基金项目(2022MS03065)。

摘　　要：捻转血矛线虫对伊维菌素、阿苯达唑等驱虫药物的耐药性愈发严重,给全球多数国家和地区的养殖业带来巨大损失。目前,对捻转血矛线虫耐药性的研究多集中于流行病学调查、耐药机制及耐药性干预,并取得一定进展。本文针对捻转血矛线虫的耐药性分布及其影响因素,耐药机制以及基于细胞膜泵、自噬水平、细胞呼吸链、寄生虫替换、植物提取物与驱虫药联合驱虫、抗性宿主培育等途径逆转耐药性进行综述,以期为捻转血矛线虫的耐药性研究提供新的思路,同时为捻转血矛线虫病的科学防治、合理用药以及新药开发提供参考依据。The resistance of Haemonchus contortus to anthelmintics such as ivermectin and albendazole has become increasingly serious,causing major losses to the aquaculture industry in most countries and regions of the world.Currently,research on drug resistance in Haemonchus contortus focuses on epidemiological studies,drug resistance mechanisms and drug resistance interventions,and has made some progress.In this paper,we review the distribution of drug resistance and its influencing factors,the mechanism of drug resistance and reversal of drug resistance based on cell membrane pumps,autophagy level,cellular respiratory chain,parasite substitution,combined deworming with plant extracts and anthelmintics,and breeding of resistant hosts,to provide a new way of thinking for the study of drug resistance in Haemonchus contortus,and to provide reference bases for the scientific control of Haemonchus contortus,the rational use of drugs,and the development of new drugs.It also provides a reference base for scientific control,rational use of drugs and development of new drugs.

关 键 词：捻转血矛线虫 耐药分布 耐药机制 耐药性逆转 

分 类 号：S852.73[农业科学—基础兽医学]