结合外源性刺激调节免疫促进骨再生的研究进展  

Research Progress on the Modulation of Immunity by Combining Exogenous Stimulation to Promote Bone Regeneration

作　　者：张雪 稂雨繁 赵航 刘思宇 段毅 罗卫华[1,2,3] ZHANG Xue;LANG Yufan;ZHAO Hang;LIU Siyu;DUAN Yi;LUO Weihua(College of Material Science and Engineering,Central South University of Forestry and Technology,Changsha 410004,China;Hunan Provincial Key Laboratory of Materials Surface&Interface Science and Technology,Central South University of Forestry and Technology,Changsha 410004,China;Hunan Provincial Engineering Research Center of Woody Biomass Conversion,Central South University of Forestry&Technology,Changsha 410004,China)

机构地区：[1]中南林业科技大学材料科学与工程学院,湖南长沙410004 [2]中南林业科技大学材料表界面科学与技术湖南省重点实验室,湖南长沙410004 [3]中南林业科技大学湖南省木本生物质转化工程技术研究中心,湖南长沙410004

出　　处：《聊城大学学报(自然科学版)》2025年第2期278-285,共8页Journal of Liaocheng University:Natural Science Edition

基　　金：湖南省自然科学基金项目(2023JJ31009)资助。

摘　　要：骨组织工程支架植入人体时,往往引发一系列不同程度的炎症影响骨修复治疗效果。目前,临床上通常考虑在支架上负载各种生物活性因子(包括各种小分子药物、细胞因子等)来改善这个问题,但是这一方法除了存在不可控性外,还会因为剂量问题在人体中引发耐药性、毒性等副反应的发生,增加治疗成本,降低骨再生效果。本文综述了近年来结合近红外光、电、磁、超声等外源性刺激时空调控免疫微环境促进骨再生的研究现状,分析了其目前存在的问题与不足,并对未来的研究和临床应用提出了展望。Bone tissue engineering scaffolds,when implanted in the body,often trigger a series of different degrees of inflammation affecting the outcome of bone repair treatment.At present,clinics usually consider loading various bioactive factors(including various small molecule drugs,cytokines,etc.)on the scaffolds to improve this problem,but this method,in addition to the uncontrollability,will also trigger the occurrence of resistance,toxicity and other side effects in the human body due to dosage problems,increasing the cost of treatment and decreasing the effectiveness of bone regeneration therapy.In this paper,we review the current research status of combining near-infrared light,electricity,magnetism,ultrasound and other exogenous stimulation of spatiotemporal modulation of the immune microenvironment to promote bone regeneration in recent years,analyze its current problems and shortcomings,and put forward a prospect for the future research and clinical application.

关 键 词：外源性刺激 时空调控 免疫微环境 骨再生 

分 类 号：R392[医药卫生—免疫学]