重组结核杆菌融合蛋白皮肤试验筛查HIV/AIDS患者中结核潜伏感染的影响因素研究  

Influencing factors of latent tuberculosis infection among persons living with HIV/AIDS test by recombinant mycobacterium tuberculosis fusion protein

作　　者：王慧 卜春红 陆兴 王金富 竺丽梅[3] 刘巧[3] WANG Hui;BU Chunhong;LU Xing;WANG Jinfu;ZHU Limei;LIU Qiao(Yangzhou Center for Disease Control and Prevention,Yangzhou,Jiangsu 22500,China;The Third People's Hospital of Yangzhou;Jiangsu Provincial Center for Disease Control and Prevention)

机构地区：[1]扬州市疾病预防控制中心,江苏扬州225000 [2]扬州市第三人民医院 [3]江苏省疾病预防控制中心

出　　处：《华南预防医学》2024年第12期1124-1129,共6页South China Journal of Preventive Medicine

基　　金：扬州市科技计划软课题研究项目(No.YZ2023305);江苏省卫生健康委科研项目(ZDA2020022);国家自然科学基金青年科学基金项目(82003516)。

摘　　要：目的 研究重组结核杆菌融合蛋白皮肤试验(EC-ST)筛查人免疫缺陷病毒/获得性免疫缺陷综合征(HIV/AIDS)患者中结核分枝杆菌潜伏感染(LTBI)的阳性率及影响因素,为HIV/AIDS患者的结核病防治提供依据。方法 选取2023年4月1日至2023年6月30日期间,需随访检测CD4+T淋巴细胞计数且符合条件的549例HIV/AIDS患者为研究对象,对其进行EC-ST检测,根据筛查结果将患者分为LTBI组和非LTBI组,探讨影响EC-ST诊断LTBI阳性率的因素。利用R语言建立限制性立方样条,分析CD4+T淋巴细胞水平与LTBI风险之间的关系。结果 CD4+T淋巴细胞水平(OR=1.002)是EC-ST筛查HIV/AIDS患者LTBI阳性率的影响因素,且与LTBI风险之间呈线性关系(非线性检验χ2=0.140,P>0.05)。结论 EC-ST在HIV/AIDS患者中筛查LTBI阳性率受CD4+T淋巴细胞水平影响。需加强HIV/AIDS患者中LTBI者健康教育与预防性治疗,重点关注对CD4+T淋巴细胞水平较低,提示有重度免疫缺陷的HIV/AIDS患者,定期对其进行LTBI筛查及健康监测。Objective To investigate the positive rate and influencing factors of recombinant mycobacterium tu‑berculosis fusion protein skin test(EC-ST)for screening latent tuberculosis infection(LTBI)in human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)patients,to provide the basis for prevention and treatment of tuber‑culosis in HIV/AIDS patients.Methods From April 1,2023 to June 30,2023,549 eligible HIV/AIDS patients requiring CD4+T lymphocyte count detection were selected as the study objects,and EC-ST detection was performed on them.Ac‑cording to the results of EC-ST,HIV/AIDS patients were divided into LTBI group and non-LTBI group to explore the fac‑tors affecting the positive rate of LTBI.R software was used to establish a restricted cubic spline model to fit the dose-response relationship between CD4+T lymphocyte levels and the risk of LTBI.Results CD4+T lymphocyte level was an influential factor in EC-ST screening for positive rate of LTBI in HIV/AIDS patients(OR=1.002),and was linearly corre‑lated with the risk of LTBI(non-linear test c2=0.140,P>0.05).Conclusions The positive rate of LTBI in EC-ST screen‑ing in HIV/AIDS patients is influenced by the level of CD4+T lymphocytes.It is necessary to strengthen health education and preventive treatment of LTBI among HIV/AIDS patients,focusing on LTBI screening and health monitoring of HIV/AIDS patients with low CD4+T lymphoid cell levels indicating severe immune deficiency.

关 键 词：人免疫缺陷病毒 获得性免疫缺陷综合征 重组结核杆菌融合蛋白 结核潜伏感染 限制性立方条 

分 类 号：R211[医药卫生—中医学] R521R512.91