中草药抗白色念珠菌作用的研究进展  

Research progress of the effect of Chinese herbal medicines against Candida albicans

作　　者：余达浪 谢明 YU Dalang;XIE Ming(Pathogen and Immunology Teaching and Research Office,Fuzhou Medical College of Nanchang University,Fuzhou 344000,China;Department of Human Anatomy,Fuzhou Medical College of Nanchang University,Fuzhou 344000,China)

机构地区：[1]南昌大学抚州医学院病原与免疫学教研室,江西抚州344000 [2]南昌大学抚州医学院人体解剖学教研室,江西抚州344000

出　　处：《大连医科大学学报》2024年第6期528-534,共7页Journal of Dalian Medical University

基　　金：江西省自然科学基金项目(20202BABL206117)。

摘　　要：白色念珠菌作为条件性致病真菌,常在宿主免疫力降低时引起各种浅表和深部真菌感染。此外,因现有抗真菌药物的数量有限及耐药性,导致白色念珠菌感染具有难治性和复发性。因此,探索高效低毒的抗真菌药物已成为研究热点。目前研究发现,许多中草药(CHMs)具有抗白色念珠菌活性,并可通过影响生物膜、细胞壁、细胞膜和线粒体等不同靶点发挥作用。本文对近年来常见中草药抗白色念珠菌的作用及相关机制的研究进展进行综述。Candida albicans(C.albicans),an opportunistic pathogenic fungus,often causes various superficial and deep fungal infections when the host's immune system is compromised.The number of existing antifungal drugs is limited and the emergence of drug resistance has contributed to the refractory and recurrent nature of C.albicans infections.Therefore,exploring efficient and low toxicity antifungal drugs has become a research hotspot.Recent research has found that many Chinese herbal medicines(CHMs)exhibit antifungal activity against C.albicans,acting on various targets such as biofilms,cell walls,cell membranes,and mitochondria.This article reviews the research progress on the antifungal effects and mechanisms of commonly used CHMs against C.albicans in recent years.

关 键 词：白色念珠菌 中草药 机制 

分 类 号：R37[医药卫生—病原生物学]