回音壁微腔协同的表面增强拉曼散射生物传感  

SERS Biosensing Synergistically Enhanced by Whispering Gallery Mode Microcavity

作　　者：夏伟 邓麦雨 雍蓉蓉 石增良 徐春祥[1] XIA Wei;DENG Maiyu;YONG Rongrong;SHI Zengliang;XU Chunxiang(School of Electronic Science&Engineering,School of Biological Science and Medical Engineering,Southeast University,Nanjing 211189,China)

机构地区：[1]东南大学电子科学与工程学院,生物科学与医学工程学院,江苏南京211189

出　　处：《发光学报》2025年第2期229-244,共16页Chinese Journal of Luminescence

基　　金：国家自然科学基金(62375049,62335003,62075041,61821002)。

摘　　要：表面增强拉曼散射(Surface enhanced Raman scattering,SERS)技术是一种具有高灵敏度、高选择性且无损的光谱分析方法,有效解决了拉曼散射信号微弱的问题。经过数十年的发展,SERS生物传感技术在增强机理的揭示、增强材料的开发、高性能基底的制备以及新型SERS检测技术和设备的开发等方面取得了显著进展。然而,设计与制备高性能SERS基底以及开发新型检测技术仍然是实现定量生物传感和复杂物质鉴别的关键问题。回音壁模(Whispering gallery mode,WGM)光学微腔是增强光与物质相互作用的重要技术手段,结合SERS技术,能充分发挥WGM和SERS效应的协同作用优势,有望实现拉曼散射信号的双重增强。本文从电磁场增强、化学增强及协同增强三个方面阐述了SERS的增强原理,主要以氧化锌(ZnO)材料为例分析了半导体及金属-半导体复合体系的SERS增强机制,探讨了光学谐振腔体系中的SERS协同作用,并综述近年来WGM微腔协同的SERS生物传感方面的最新研究进展。Surface-enhanced Raman scattering(SERS)technology is a highly sensitive,selective,and non-destructive spectroscopic analysis method that effectively addresses the challenge of weak Raman scattering signals.Over the past few decades,significant progress has been made in SERS biosensing technology,including the understanding of enhancement mechanisms,development of enhancement materials,preparation of high-performance substrates,and the creation of novel SERS detection technologies and equipment.However,the design and preparation of high-performance SERS substrates and the development of novel SERS detection technologies remain necessary to achieve quantitative biosensing and the identification of complex substances.Whispering gallery mode(WGM)optical microcavities can significantly enhance the interaction between the light field and matter within the cavity.The combination of WGM microcavity and SERS technology can give full play to the synergistic coupling advantages of WGM effect and SERS effect,and it is expected to realize the double enhancement of Raman scattering.In this paper,the SERS enhanced mechanism was elaborated from electromagnetic field enhancement,chemical enhancement and their synergistic enhancement.The SERS enhanced mechanism of semiconductor materials and metal-semiconductor composite system was analyzed with zinc oxide(ZnO)as the representative.The SERS synergism in optical resonator system was discussed,and the recent research progress of WGM microcavity in synergistically enhancing SERS biosensing was reviewed.

关 键 词：表面增强拉曼散射 生物传感 回音壁模微腔 

分 类 号：O482.31[理学—固体物理]