毒性药材专题知识库构建及应用  

Construction and Application of Knowledge Base for Toxic Herbal Materials

作　　者：李小阳 王贻琳 许静 佟琳[1] 翟敏 蒋文博 何燕贤 雷蕾[1] 游云[2] LI Xiaoyang;WANG Yilin;XU Jing;TONG Lin;ZHAI Min;JIANG Wenbo;HE Yanxian;LEI Lei;YOU Yun(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;BeiDou Satellite Global Navigation Co.,LTD,Beijing 100160,China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]中国中医科学院中药研究所,100700 [3]北斗天下卫星导航有限公司,北京100160

出　　处：《中国药物警戒》2024年第12期1415-1418,1424,共5页Chinese Journal of Pharmacovigilance

基　　金：中国中医科学院科技创新工程(毒性药材专题知识库构建及应用CI2021A03709);国家自然科学基金资助项目(82274244)。

摘　　要：目的探讨建立毒性药材知识库,为安全使用中药材提供参考。方法研究采用知识图谱存储结构结合可视化技术组织毒性药材的毒性靶器官、毒性剂量等信息,搭建毒性药材可视化平台。结果研究构建的毒性药材专题知识库对毒性药材、含有毒性药材的中成药和毒性成分的毒性实验报道分别进行系统汇总,实现毒性药材知识整合和数据关联性的提高。结论本平台将为有毒中药的应用研究、发展和传承提供数据服务支撑。Objective To establish a knowledge base of toxic traditional Chinese medicine.Methods A knowledge graph storage structure combined with visualization technology was adopted to present the information about the toxin-targeted organs and toxic doses.A visualization platform was built for toxic medicinal materials.Results The knowledge base exclusively related to toxic traditional Chinese medicine constructed by the study summarized the reports about toxic experiments on toxic traditional Chinese medicine,traditional Chinese patent medicines and simple preparations containing toxic traditional Chinese medicine and toxic ingredients,integrated the knowledge of toxic traditional Chinese medicine and kept data more correlated.Conclusion This platform will provide data service support for the applicational research,development,and inheritance of toxic traditional Chinese medicine.

关 键 词：毒性药材 知识库构建 知识图谱 药品不良反应 毒性剂量 

分 类 号：R917[医药卫生—药物分析学]