生长因子促进膝软骨再生:研究热点的文献计量学分析  

Growth factors promote knee cartilage regeneration:a bibliometric analysis of research hotspots

作　　者：柳剑 刘庆 黄野 曹光磊 刘源 宋卿鹏 Liu Jian;Liu Qing;Huang Ye;Cao Guanglei;Liu Yuan;Song Qingpeng(Department of Knee Preservation Surgery,Beijing Jishuitan Hospital Affiliated to Capital Medical University,Beijing 102208,China)

机构地区：[1]首都医科大学附属北京积水潭医院保膝外科,北京市102208

出　　处：《中国组织工程研究》2025年第29期6351-6359,共9页Chinese Journal of Tissue Engineering Research

摘　　要：背景:膝软骨缺损导致的接触面积减小、边缘负荷和邻近区域软骨的应力增加,被认为容易使该组织发生退行性变化,可发展为膝骨关节炎。生长因子被认为是促进损伤软骨愈合和延缓退化性关节炎进展的治疗方法。目的:采用文献计量学方法分析生长因子促进膝软骨再生研究的热点和前景。方法:由第一作者检索Web of Science核心集数据库中与生长因子促进膝软骨再生研究相关的文献321篇,采用VOSviewer 1.6.19软件对文献的发文量、国家、机构、关键词及文献被引情况进行分析,剖析研究热点。结果与结论:①从2000-2024年,生长因子促进膝软骨再生领域的年度发文量总体呈上升趋势,其中2021年发文量最高。美国哈佛大学发文量最高。②关键词分析显示,生长因子、软骨、软骨修复、富血小板血浆及软骨再生等关键词频次较高。此外,关键词共现网络图显示,生长因子与软骨修复、软骨再生等关键词联系紧密,说明生长因子在软骨再生领域的研究具有重要地位。③文献被引情况分析结果显示,将富血小板血浆与肌肉来源干细胞结合使用,可能为骨关节炎患者提供一种新的有效治疗策略,可通过促进干细胞增殖和软骨形成来加深对软骨修复机制的理解。成纤维细胞生长因子2、成纤维细胞生长因子18、胰岛素生长因子1在软骨修复中扮演关键角色,能够促进软骨细胞增殖和基质合成,尤其是成纤维细胞生长因子18可以促进受损软骨的修复,从而缓解患者的疼痛和功能障碍,未来值得进一步深入研究。最新的研究开发了一种新型生长因子递送系统(PODS),能够持续释放骨形态发生蛋白2,7等生长因子,显著促进软骨细胞增殖和软骨修复,此系统为治疗骨关节炎提供了新的视角和潜在疗法。④因此,骨形态发生蛋白2,7,胰岛素生长因子1和重组人成纤维细胞生长因子18是很有前景的促�BACKGROUND:The reduction of contact area,edge load,and stress increase of adjacent cartilage caused by knee cartilage defect are considered to easily cause degenerative changes in this tissue,which may develop into knee osteoarthritis.Growth factors are considered to be a treatment method to promote the healing of damaged cartilage and delay the progression of degenerative arthritis.OBJECTIVE:To analyze the hotspots and prospects of growth factor-promoted knee cartilage regeneration research by bibliometric methods.METHODS:The first author retrieved 321 articles related to growth factor-promoted knee cartilage regeneration research from the Web of Science core set database.VOSviewer 1.6.19 software was used to analyze the publication volume,country,institution,keyword,and literature citation status of the articles,and investigate the research hotspots.RESULTS AND CONCLUSION:(1)From 2000 to 2024,the annual number of publications in the field of growth factor-promoted knee cartilage regeneration showed an overall upward trend,with the highest number of publications in 2021.Harvard University in the United States published the most papers.(2)Keyword analysis showed that the frequency of keywords such as growth factor,cartilage,cartilage repair,platelet-rich plasma,and cartilage regeneration was high.In addition,the keyword co-occurrence network diagram showed that growth factor was closely related to keywords such as cartilage repair and cartilage regeneration,indicating that growth factor research plays an important role in the field of cartilage regeneration.(3)The results of literature citation analysis showed that the combination of platelet-rich plasma and muscle-derived stem cells may provide a new and effective treatment strategy for patients with osteoarthritis,which can deepen the understanding of cartilage repair mechanisms by promoting stem cell proliferation and cartilage formation.Fibroblast growth factor 2,fibroblast growth factor 18,and insulin growth factor 1 play a key role in cartilage repair and c

关 键 词：生长因子 软骨 软骨再生 膝 骨形态发生蛋白 胰岛素生长因子 成纤维细胞生长因子 文献计量学 文献可视化 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R605