骨质疏松症相关长链非编码RNA:研究现状及发展趋势  

Long noncoding RNAs related to osteoporosis:current research status and developmental trends

作　　者：吴王祥 冉栋成 许嘉木 胥家福 陈晶晶 王春庆 Wu Wangxiang;Ran Dongcheng;Xu Jiamu;Xu Jiafu;Chen Jingjing;Wang Chunqing(School of Clinical Medicine,Guizhou Medical University,Guiyang 550004,Guizhou Province,China;Department of Emergency Surgery,Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou Province,China)

机构地区：[1]贵州医科大学临床医学院,贵州省贵阳市550004 [2]贵州医科大学附属医院急诊外科,贵州省贵阳市550004

出　　处：《中国组织工程研究》2025年第29期6360-6368,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(82060271),项目负责人:王春庆。

摘　　要：背景:研究发现长链非编码RNA在骨质疏松症的发生和发展中扮演着重要的角色,因此了解长链非编码RNA在骨质疏松领域的研究现状、热点及发展趋势尤为重要。目的:通过对骨质疏松症相关长链非编码RNA研究进行文献计量学统计及可视化分析,以期探索该领域的研究现状、发展趋势与研究热点。方法:以“(TS=(Osteoporosis OR Osteoporoses)AND TS=(Long non coding RNA OR LncRNA OR Lnc RNA OR Long noncoding RNA))”为检索式,对2015年1月至2024年9月在Web of Science核心合集数据库中的文献进行主题词检索。检索获得的原始数据经过人工排除筛选后,应用Cite Space 6.2.R4软件及微软Microsoft 365(office)对作者、机构、国家以及关键词进行可视化分析。结果与结论:共纳入265篇文献,自2015年来,骨质疏松症相关长链非编码RNA领域发文量总体呈上升趋势,研究中心性和发文量最高的国家均为中国,研究中心性最高的机构为北京航空航天大学。去除与文章主题直接相关的关键词,综合共现频率及中心性,“osteogenic differentiation”“expression”“bone formation”和“mesenchymal stem cells”处于骨质疏松症相关长链非编码RNA研究领域较为核心的地位。综合关键词聚类图谱、关键词突现图谱及关键词时间线图,探究长链非编码RNA针对成骨细胞的形成以及分化、破骨细胞的分化及骨吸收的分子作用机制等是骨质疏松症相关长链非编码RNA领域目前的研究热点,也是未来的研究趋势。BACKGROUND:Studies have indicated that long noncoding RNAs play a crucial role in the pathogenesis and progression of osteoporosis.Thus,it is essential to comprehend the current research status,hotspots,and developmental trajectories of long noncoding RNAs in the field of osteoporosis research.OBJECTIVE:To explore the research status,development trends,and hotspots in the field of osteoporosis-related long noncoding RNAs by conducting bibliometric statistics and visualization analysis of the relevant literature.METHODS:Using the search string“(TS=(Osteoporosis OR Osteoporoses)AND TS=(Long non coding RNA OR LncRNA OR Lnc RNA OR Long noncoding RNA)),”a subject term search was conducted in the Web of Science Core Collection database for articles published from January 2015 to September 2024.After manual filtering of the obtained raw data,visualization analysis of authors,institutions,countries,and keywords was performed using Cite Space 6.2.R4 software and Microsoft 365(Office).RESULTS AND CONCLUSION:A total of 265 articles were included from the Web of Science Core Collection database.Since 2015,there has been an overall upward trend in the number of publications in this field,with China being the leading country in terms of publication volume and research centrality,while Beihang University holds the highest institutional centrality.After keywords directly related to the article’s theme were excluded,the terms“osteogenic differentiation,”“expression,”“bone formation,”and“mesenchymal stem cells”emerged as core topics based on co-occurrence frequency and centrality.A comprehensive analysis of the keyword cluster map,keyword burst map,and keyword timeline map reveals that investigating the mechanisms by which long non-coding RNAs influence the formation and differentiation of osteoblasts,as well as the differentiation of osteoclasts and bone resorption,constitutes both a current research hotspot and a future research trend in this field.

关 键 词：骨质疏松症 长链非编码RNA 文献计量学 可视化分析 Cite Space 成骨细胞 破骨细胞 分化 

分 类 号：R446.9[医药卫生—诊断学] R394.3[医药卫生—临床医学] R681