布比卡因脂质体用于髋关节囊周围神经阻滞对老年股骨粗隆间骨折术后镇痛效果的影响  

Influence on bupivacaine liposomes applying to pericapsular nerve group block on analgesic effect after senile surgery of intertrochanteric fracture of femur

作　　者：梁然[1] 王睿 胡鹏[1] 唐巧 滕琦[1] 刘萍 刘敏[1] 李王明 王静 LIANG Ran;WANG Rui;HU Peng;TANG Qiao;TENG Qi;LIU Ping;LIU Min;LI Wangming;WANG Jing(Department of Anesthesiology,Lianyungang Hospital of TCM,Lianyungang 222004,Jiangsu,China)

机构地区：[1]连云港市中医院(南京中医药大学连云港附属医院)麻醉科,江苏连云港市222004

出　　处：《广西医学》2025年第1期44-48,共5页Guangxi Medical Journal

基　　金：江苏省自然科学基金(BK20201084)。

摘　　要：目的探讨布比卡因脂质体用于髋关节囊周围神经阻滞(PNGB)对老年股骨粗隆间骨折患者术后镇痛效果的影响。方法选择80例拟行手术治疗的老年股骨粗隆间骨折患者作为研究对象,随机分为观察组和对照组,每组40例。观察组接受布比卡因脂质体进行PNGB,对照组接受盐酸布比卡因进行PNGB。比较两组患者术前及术后不同时间点静息疼痛视觉模拟量表(VAS)评分和运动疼痛VAS评分、术后不同时间点芬太尼需求量、术后恶心呕吐发生率。结果在术后6h、12h、48h及72h,观察组的静息疼痛VAS评分、运动疼痛VAS评分低于对照组(P<0.05)。在术后12h、24h及48h,观察组芬太尼需求量低于对照组(P<0.05)。观察组术后恶心呕吐发生率低于对照组(P<0.05)。结论对于老年股骨粗隆间骨折患者,使用布比卡因脂质体进行PNGB能够提供更有效的术后镇痛效果,减少患者术后对镇痛药的需求量,降低术后恶心呕吐发生率。Objective To explore the influence on bupivacaine liposomes applying to pericapsular nerve group block(PNGB)on analgesic effect in senile patients with intertrochanteric fracture of femur after surgery.Methods A total of 80 senile patients with intertrochanteric fracture of femur who were proposed to receive surgical treatment were selected as the research subjects,and they were randomly assigned to observation group or control group,with 40 cases in each group.The observation group received bupivacaine liposomes for PNGB,whereas the control group received bupivacaine hydrochloride for PNGB.Visual Analogue Scale(VAS)score for resting pain and VAS score for exercise pain at different time points before and after surgery,fentanyl demand at different time points after surgery,and the incidence rate of postoperative nausea and vomiting were compared between patients of the two groups.Results The observation group exhibited lower VAS scores for resting pain and exercise pain as compared with the control group 6,12,48,and 72 hours after surgery(P<0.05).The observation group yielded lower fentanyl demand as compared with the control group 12,24,and 48 hours after surgery(P<0.05).The incidence rate of nausea and vomiting in the observation group after surgery was lower than that in the control group(P<0.05).Conclusion For senile patients with intertrochanteric fracture of femur,employing bupivacaine liposomes for PNGB can provide more effective postoperative analgesic effect,reduce patients'demands for analgesic drug after surgery,and decrease the incidence rate of nausea and vomiting after surgery.

关 键 词：股骨粗隆间骨折 布比卡因脂质体 髋关节囊周围神经阻滞 镇痛 老年人 

分 类 号：R614.3[医药卫生—麻醉学]