磷酸奥司他韦治疗儿童流行性感冒病毒感染的临床疗效及对免疫功能的影响  

Clinical Efficacy of Oseltamivir Phosphate in the Treatment of Children with Influenza Virus Infection and the Effect on Immune Function

作　　者：王秋梅 WANG Qiumei(Department of Pediatrics,Ganyu District People's Hospital,Lianyungang 222100,Jiangsu,China)

机构地区：[1]连云港市赣榆区人民医院儿科,江苏连云港222100

出　　处：《世界复合医学(中英文)》2024年第10期31-34,共4页World Journal of Complex Medicine

摘　　要：目的 探究磷酸奥司他韦在流行性感冒(简称流感)病毒感染患儿中的应用价值。方法 选取2023年5—12月连云港市赣榆区人民医院收治的142例流感病毒患儿,依据治疗方法的不同分为对照组(71例,采取常规治疗)、研究组(71例,在对照组基础上结合磷酸奥司他韦颗粒治疗)。对比两组临床疗效、症状改善时间、免疫功能与炎症因子水平。结果 研究组患者的治疗总有效率是97.18%(69/71),高于对照组的88.73%(63/71),差异有统计学意义(χ^(2)=4.873,P<0.05)。治疗后,研究组发热消退时间、乏力消失时间以及病毒检测转阴时间均短于对照组,研究组CD3^(+)、CD4^(+)、CD8^(+)水平均优于对照组,研究组的血清淀粉样蛋白A、C反应蛋白、白细胞介素-6、γ干扰素水平均低于对照组,差异有统计学意义(P均<0.05)。结论 磷酸奥司他韦治疗儿童流感病毒感染,能够提高临床疗效、促进症状缓解、提高免疫功能、降低炎症反应。Objective To research the application value of oseltamivir phosphate in children with influenza virus infection.Methods A total of 142 children with influenza virus admitted to Ganyu District People's Hospital of Lianyungang from May to December 2023 were selected,and divided into control group (71 cases receiving conventional treatment) and study group (71 cases receiving combined with oseltamivir phosphate granules on the basis of the control group) according to different treatment methods.The clinical efficacy,symptom improvement time,immune function and inflammatory factor levels were compared between the two groups.Results The total effective rate of treatment in the study group was 97.18%(69/71),which was higher than88.73%(63/71) in the control group,and the difference was statistically significant (χ~2=4.873,P<0.05).After tratment,the fever regression time,fatigue disappearance time and virus detection negative time of the study group were shorter than those of the control group,the levels of CD3~+,CD4~+and CD8~+in the study group were better than those in the control group,the levels of serum amyloid A,C-reactive protein,interleukin-6 and interferon-γ in the study group were lower than those of the control group,and the differences were statistically significant (all P<0.05).Conclusion Oseltamivir phosphate in the treatment of children with influenza virus infection can improve clinical efficacy,promote symptom relief,improve immune function,and reduce inflammatory response.

关 键 词：磷酸奥司他韦 流行性感冒病毒 免疫功能 炎症反应 

分 类 号：R725.6[医药卫生—儿科]