中药贴敷疗法联合双歧杆菌四联活菌片治疗小儿病毒性肠炎的效果及对炎症水平及肠道菌群的影响  

Effect of Traditional Chinese Medicine Sticking Therapy Combined with Bifidobacterium Quadruple Live Bacteria Tablets in the Treatment of Viral Enteritis in Children and Its Effect on Inflammation Level and Intestinal Flora

作　　者：谭英阁 郑茗贞 TAN Yingge;ZHENG Mingzhen(Department of PediatricsⅠ,Yuncheng County People's Hospital,Heze 274700,Shandong,China)

机构地区：[1]郓城县人民医院儿一科,山东菏泽274700

出　　处：《世界复合医学(中英文)》2024年第10期61-64,69,共5页World Journal of Complex Medicine

摘　　要：目的 评估小儿病毒性肠炎给予双歧杆菌四联活菌片治疗联合中药贴敷疗法的作用及对患儿炎症和肠道菌群的影响。方法 选取2022年1月—2023年12月郓城县人民医院收治的76例小儿病毒性肠炎患儿为研究对象,根据治疗方法的不同分为两组,每组38例。西医组提供双歧杆菌四联活菌片治疗,中西医结合组在西医组的基础上增加中药贴敷疗法。比较两组炎症因子水平、肠道菌群指标、中医证候积分。结果 治疗后,中西医结合组的C反应蛋白、白细胞介素-6、肿瘤坏死因子-α水平分别为(2.79±0.52)mg/L、(90.46±3.85)ng/mL、(1.81±0.56)pg/mL,低于西医组的(3.17±0.63)mg/L、(123.96±10.85)ng/mL、(3.10±0.85)pg/mL,差异有统计学意义(t=2.868、17.937、7.812,P均<0.05)。治疗后,中西医结合组肠道双歧杆菌、乳杆菌及大肠埃希菌水平均高于西医组,差异有统计学意义(P均<0.05)。治疗后,中西医结合组中医证候积分低于西医组,差异有统计学意义(P均<0.05)。结论对小儿病毒性肠炎提供双歧杆菌四联活菌片治疗+中药贴敷疗法可以获得显著的疗效,并降低炎症水平,提高肠道菌群指标。Objective To evaluate the effect of bifidobacterium tetravaccine tablets combined with traditional Chinese medicine sticking therapy on viral enteritis in children and its effect on inflammation and intestinal flora in children.Methods A total of 76 children with viral enteritis admitted to Yuncheng County People's Hospital from January 2022 to December 2023 were selected as the research objects and divided into two groups according to different treatment methods,with 38 cases in each group.The Western medicine group was treated with bifidobacterium quadruple live bacteria tablets,and the integrated traditional Chinese and Western medicine group was treated with traditional Chinese medicine sticking therapy on the basis of the Western medicine group.The levels of inflammatory factors,intestinal flora indexes and traditional Chinese medicine symptom scores were compared between the two groups.Results After treatment,the levels of C-reactive protein,interleukin-6 and tumor necrosis factor-α in the integrated traditional Chinese and Western medicine group were(2.79±0.52) mg/L,(90.46±3.85) ng/mL and(1.81±0.56) pg/mL,respectively,which were lower than(3.17±0.63) mg/L,(123.96±10.85) ng/mL and(3.10±0.85) pg/mL in the Western medicine group,and the differences were statistically significant(t= 2.868,17.937,7.812,all P<0.05).After treatment,the levels of intestinal bifidobacteria,lactobacillus and escherichia coli in the integrated traditional Chinese and Western medicine group were higher than those in the Western medicine group,and the differences were statistically significant(all P<0.05).After treatment,the traditional Chinese medicine symptom scores of the integrated traditional Chinese and Western medicine group were lower than those of the Western medicine group,and the differences were statistically significant(all P<0.05).Conclusion The treatment of bifidobacterium quadruple live bacteria tablets+traditional Chinese medicine sticking therapy for viral enteritis in children can achieve significant curative

关 键 词：小儿病毒性肠炎 中药贴敷疗法 双歧杆菌四联活菌片 炎症因子水平 肠道菌群 

分 类 号：R72[医药卫生—儿科]