中药治疗手足综合征的研究进展  

Current Research Status and Advances in Traditional Chinese Medicine in the Treatment of Hand-foot Synd rome

作　　者：金鑫 赵勃 方晴 徐作钧 林杭娟 JIN Xin;ZHAO Bo;FANG Qing;XU Zuojun;LIN Hangjuan(Department of Pharmacy,Ningbo Hospital of Traditional Chinese Medicine(Ningbo Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University),Zhejiang Province,Ningbo 315010,China)

机构地区：[1]宁波市中医院/浙江中医药大学附属宁波中医院药学部,浙江宁波315010

出　　处：《光明中医》2025年第1期160-163,共4页GUANGMING JOURNAL OF CHINESE MEDICINE

基　　金：宁波市科学技术局公益类科技计划项目(No.2021S160);宁波市科学技术局自然科学基金一般项目(No.202003N4217)。

摘　　要：手足综合征(Hand-foot syndrome,HFS)是肿瘤患者使用化疗药物或靶向药物后产生的常见不良反应,表现为手足肿痛。现代医学认为其发生机制可能与炎症反应、药物直接毒性作用和药物代谢物毒性作用有关。西医应对HFS通常为将化疗药停药减量,或使用止痛药、激素等药物疗法。相比于西医疗法,中医辨证论治下的中医药疗法具有疗效佳、毒性低、直达病所等优势。现对HFS的西医发病机制理论、中医病因病机和辨证论治,以及近年来中医药在临床中治疗HFS的研究进展展开综述。Hand-foot syndrome(HFS),a common adverse reaction in cancer patients following chemotherapy or targeted therapy,is characterized by pain,swelling,and erythema of the palms and soles.Modern medicine suggests its pathogenesis may involve the promotion of inflammatory responses,direct drug toxicity,and the toxic effects of drug metabolites.Western medical management typically entails dose reduction or discontinuation of chemotherapy,along with the use of analgesics and corticosteroids.In contrast,traditional Chinese medicine(TCM),guided by syndrome differentiation and treatment principles,offers a therapeutic approach involving Chinese herbal medicine known for its superior efficacy,lower toxicity,and direct targeting of the affected area.This review article provided an overview of the Western medical theories regarding HFS pathogenesis,TCM etiology,and pathogenesis,and recent advancements in clinical research on the use of Chinese herbal medicine in the treatment of HFS.

关 键 词：手足综合征 化疗药物 中医理论 中药 综述 

分 类 号：R273[医药卫生—中西医结合]