2018年—2023年西安市500例宫颈癌患者HR-HPV感染情况及危险因素分析  

Analysis of high-risk human papilloma virus infection in 500 cases cervical cancer patients in Xi′an from 2018 to 2023 and risk factors

作　　者：孙娜 彭帅 SUN Na;PENG Shuai(Department of Obstetrics and Gynecology,Tangdu Hospital,Second Affiliated Hospital of Air Force Medical University,Xi′an 710038,Shaanxi,China)

机构地区：[1]空军军医大学第二附属医院唐都医院妇产科,西安710038

出　　处：《中国性科学》2025年第2期70-73,共4页Chinese Journal of Human Sexuality

基　　金：陕西省科技统筹创新工程计划项目(2018TZC-S-15-13)。

摘　　要：目的分析西安市宫颈癌患者高危型人乳头瘤病毒(HR-HPV)感染情况及相关危险因素。方法选取2018年—2023年空军军医大学第二附属医院唐都医院收治的500例宫颈癌患者作为研究对象,均进行人乳头瘤病毒(HPV)基因亚型检测。分析患者HR-HPV感染情况,采用Logistic回归模型分析宫颈癌患者感染HR-HPV的影响因素。结果HR-HPV阳性患者384例,阳性率为76.80%;宫颈鳞癌和腺癌患者HR-HPV感染率分别为77.49%和75.68%;HPV16(48.96%)和HPV18(12.50%)是最常见的感染亚型。患者年龄、初次性行为年龄、分娩次数、性伴侣数、是否绝经及是否有宫颈炎病史是宫颈癌患者感染HR-HPV的影响因素(P<0.05)。年龄>50岁和已绝经是宫颈癌患者感染HR-HPV的保护因素,初次性行为年龄≤20岁和分娩次数>2次是宫颈癌患者感染HR-HPV的独立危险因素(P<0.05)。结论西安市宫颈癌患者HR-HPV感染率较高,以HPV16和HPV18亚型为主,初次性行为年龄较小和分娩次数较多会增加HR-HPV感染风险。Objective To analyze the infection status of high risk-human papilloma virus(HR-HPV)among cervical cancer patients in Xi′an and its related factors.Methods A total of five hundred cervical cancer patients admitted to the Tangdu Hosptal,Second Affiliated Hospital of Air Force Medical University from 2018 to 2023 were selected as the research,and all of them underwent human papilloma virus(HPV)sub-genotype detection.The HR-HPV infection status of the patients was analyzed,and influencing factors of HR-HPV infection in cervical cancer patients were analyzed using the Logistic regression model.Results There were 384 cases of HR-HPV positive patients,with a positive rate of 76.80%;the infection rates HR-HPV in patients with cervical squamous cell carcinoma and adenocarcinoma were 77.49%and 75.68%respectively;HPV16(48.96%)and HPV18(12.50%)were the most common subtypes of infection.Patient age,age at first sexual intercourse,number of deliveries,number of sexual partners,whether menopause has occurred,and history of cervical inflammation were influencing factors for HR-HPV infection in patients with cervical cancer(P<0.05).Age>50 year-old and having menopause were protective factors for HR-HPV infection in cervical cancer patients,while age of first sexual intercourse≤20 year-old and number of deliveries>2 were independent risk factors for HR-HPV infection in cervical cancer patients(P<0.05).Conclusions The HR-HPV infection rate among cervical cancer patients in Xi′an is high,mainly characterized by HPV16 and HPV18 subtypes.Younger age at first sexual intercourse and higher number of deliveries will increase the risk of HR-HPV infection.

关 键 词：宫颈癌 人乳头瘤病毒 基因分型 危险因素 

分 类 号：R711[医药卫生—妇产科学]