头孢曲松钠联合苄星青霉素对不同孕周妊娠期梅毒孕妇妊娠结局、新生儿阿普加评分和胎传梅毒的影响  

Effects of ceftriaxone sodium combined with benzathine penicillin on pregnancy outcome,neonatal Apgar score and fetal transmission of syphilis insyphilis pregnant women with different gestational weeks

作　　者：路瑞娟 刘双龙 张瑞红 仇晓霞 刘翠萍 LU Ruijuan;LIU Shuanglong;ZHANG Ruihong;QIU Xiaoxia;LIU Cuiping(Department of Dermatology,the Second People′s Hospital of Gansu Province,Lanzhou 730000,Gansu,China;Department of Pediatrics,Maqu County People′s Hospital,Maqu Tibetan Autonomous Prefecture of Ganan 747300,Gansu,China;Department of Obstetrics and Gynecology,Maqu County People′s Hospital,Maqu Tibetan Autonomous Prefecture of Ganan 747300,Gansu,China;Department of Obstetrics and Gynecology,the Second People′s Hospital of Gansu Province,Lanzhou 730000,Gansu,China;Department of Otolaryngology,the Second People′s Hospital of Gansu Province,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃省第二人民医院皮肤科,兰州730000 [2]玛曲县人民医院儿科,甘肃甘南藏族自治州玛曲县747300 [3]玛曲县人民医院妇产科,甘肃甘南藏族自治州玛曲县747300 [4]甘肃省第二人民医院妇产科,兰州730000 [5]甘肃省第二人民医院耳鼻咽喉科,兰州730000

出　　处：《中国性科学》2025年第2期132-135,共4页Chinese Journal of Human Sexuality

基　　金：甘肃省自然科学基金项目(21JR11RA163)。

摘　　要：目的探讨头孢曲松钠联合苄星青霉素对不同孕周妊娠期梅毒孕妇妊娠结局、新生儿阿普加评分和胎传梅毒的影响。方法选取2020年1月至2023年12月甘肃省第二人民医院和玛曲县人民医院收治的180例妊娠期梅毒孕妇作为研究对象,根据不同孕周分为A组(孕期<12周)、B组(孕期12~27周)和C组(孕期>27周),各60例。三组均给予头孢曲松钠联合苄星青霉素治疗。比较三组妊娠结局、新生儿阿普加评分、母婴梅毒滴度情况。结果A组早产率低于B组、C组,足月分娩率高于B组、C组(P<0.05)。A组新生儿1 min和5 min阿普加评分均高于B组、C组(P<0.05)。A组母体和新生儿梅毒快速血浆反应素环状卡片试验(RPR)滴度<1∶8比率高于B组、C组,B组高于C组(P<0.05)。结论头孢曲松钠联合苄星青霉素尽早治疗妊娠期梅毒患者可有效防止母婴传播,改善妊娠结局,提高新生儿阿普加评分,降低新生儿梅毒发生率。Objective To investigate the effects of ceftriaxone sodium combined with benzathine penicillin on pregnancy outcome,neonatal Apgar score and fetal transmission of syphilis in syphilis pregnant women with different gestational weeks.Methods A total of 180 pregnant women with syphilis who were admitted to the Second People′s Hospital of Gansu Province and the Maqu County People′s Hospital from January 2020 to December 2023 were selected as the study objects.According to different gestational weeks,they were divided into group A(<12 weeks of gestation),group B(12-27 weeks of gestation)and group C(>27 weeks of gestation),with 60 cases each.All three groups were treated with ceftriaxone sodium combined with benzathine penicillin.Pregnancy outcome,neonatal Apgar score and maternal and infant syphilis titer condition were compared among the three groups Results The preterm delivery rate of group A was lower than that of group B and group C,and the term delivery rate was higher than that of group B and group C(P<0.05).The Apgar scores at 1 min and 5 min in group A were higher than those in groups B and C(P<0.05).The ratio of maternal and neonatal syphilis rapid plasma reagin(RPR)titer<1∶8 in group A was higher than that in group B and group C,and the ratio in group B was higher than that in group C(P<0.05).Conclusions Early treatment of ceftriaxone sodium combined with benzathine penicillin can effectively prevent mother-to-child transmission,improve pregnancy outcomes,increase neonatal Apgar score and reduce the incidence of neonatal syphilis.

关 键 词：头孢曲松钠 苄星青霉素 不同孕周 妊娠期梅毒 妊娠结局 胎传梅毒 

分 类 号：R759[医药卫生—皮肤病学与性病学]