杭州地区501例男性尖锐湿疣患者HPV基因型分析及疫苗预防探讨  

Human papilloma virus genotype analysis and vaccine prevention discussion of 501 cases male patients with condyloma acuminatum in Hangzhou area

作　　者：李宇晖 李新征[1] LI Yuhui;LI Xinzheng(Department of Laboratory Medicine,Hangzhou Third People′s Hospital,Hangzhou 310009,Zhejiang,China)

机构地区：[1]杭州市第三人民医院检验科,杭州310009

出　　处：《中国性科学》2025年第2期139-143,共5页Chinese Journal of Human Sexuality

摘　　要：目的分析杭州地区男性尖锐湿疣(CA)患者人乳头瘤病毒(HPV)感染流行病学特征,为该病的早期筛查、治疗、疫苗预防等提供依据。方法回顾性分析2022年8月至2024年1月在杭州市第三人民医院皮肤性病门诊就诊的501例男性CA患者的临床资料,根据年龄不同分为≤25岁组(n=98)、>25~35岁组(n=220)、>35~45岁组(n=101)、>45~55岁组(n=44)、>55岁组(n=38)。采用聚合酶链反应体外扩增和DNA反向斑点杂交法相结合的DNA芯片技术定性检测并分析24种HPV基因型。结果在501例男性CA患者中,HPV感染386例,总体阳性率为77.05%。其中低危型中HPV6、11亚型阳性率最高,分别为35.13%和21.16%,高危型中HPV52、16亚型阳性率最高,分别为8.58%和6.19%。HPV阳性CA患者中,单一感染占比57.25%,其余多重感染占比42.75%,单一感染与多重感染中HPV6阳性率分别为49.77%、40.00%,HPV11阳性率分别为17.65%、40.61%,HPV52阳性率分别为4.52%、20.00%,HPV16阳性率分别为1.36%、16.97%。≤25岁组和>25~35岁组中HPV阳性最多,占总阳性的63.73%,各年龄组的阳性率分别为81.63%、75.45%、71.29%、84.09%、81.58%。能覆盖阳性患者全部已感染基因型的二价、四价、九价HPV疫苗分别为1.81%、44.30%、54.66%,能部分覆盖阳性患者已感染基因型的二价、四价、九价HPV疫苗分别为11.66%、73.32%、82.90%。结论杭州地区男性CA患者HPV感染低危型以HPV6、11为主,高危型以HPV52、16为主,感染情况主要为单一感染,多重感染中HPV11、16、52阳性率高于单一感染,青壮年为高发人群,四价和九价疫苗在男性CA患者HPV感染的基因型中有较好的覆盖率。Objective To analyze the epidemiological characteristics of human papilloma virus(HPV)infection in male patients with condyloma acuminatum(CA)in Hangzhou area,providing a basis for early screening,treatment,and vaccine prevention of the disease.Methods A retrospective analysis was conducted on clinical data from 501 cases male CA patients treated at the Dermatology and Venereology Clinic of Hangzhou Third People′s Hospital from August 2022 to January 2024.Patients were divided into age groups:≤25 years(n=98),>25-35 years(n=220),>35-45 years(n=101),>45-55 years(n=44),and>55 years(n=38).DNA chip technology combining polymerase chain reaction amplification in vitro and DNA reverse dot blot hybridization was used to qualitatively detect and analyze 24 HPV genotypes.Results Among the 501 male CA patients,386 were HPV infection,with an overall positivity rate of 77.05%.The highest positivity rates for low-risk types were HPV6 and HPV11,at 35.13%and 21.16%,respectively.For high-risk types,HPV52 and HPV16 had the highest positivity rates at 8.58%and 6.19%,respectively.Among HPV-positive CA patients,single infections accounted for 57.25%,and multiple infections accounted for 42.75%.The positivity rates for HPV6 in single and multiple infections were 49.77%and 40.00%,respectively;the positivity rates for HPV11 in single and multiple infections were 17.65%and 40.61%;the positivity rates for HPV52 in single and multiple infections were 4.52%and 20.00%;and the positivity rates or HPV16 in single and multiple infections were 1.36%and 16.97%.The≤25 years and>25-35 groups had the highest number of HPV positives,accounting for 63.73%of total positives,with positivity rates of 81.63%,75.45%,71.29%,84.09%,and 81.58%across age groups.The bivalent,quadrivalent,and nonavalent HPV vaccines covered all infected genotypes in 1.81%,44.30%,and 54.66%of positive patients,respectively,and partially covered infected genotypes in 11.66%,73.32%,and 82.90%of positive patients.Conclusions In male CA patients in Hangzhou area,low-risk HPV ty

关 键 词：尖锐湿疣 人乳头瘤病毒 基因型 男性 

分 类 号：R759[医药卫生—皮肤病学与性病学]