肥胖儿童肺功能与代谢指标的相关性研究  

Correlation between pulmonary function and metabolic indexes in obese children

作　　者：张丽娜 万乃君 ZHANG Lina;WAN Naijun(Department of Pediatrics,Beijing Jishuitan Hospital,Capital Medical University,Beijing 100096,China)

机构地区：[1]首都医科大学附属北京积水潭医院儿科,北京100096

出　　处：《临床肺科杂志》2025年第3期348-353,共6页Journal of Clinical Pulmonary Medicine

基　　金：北京市医院管理局儿科学科协同发展中心儿科专项重点项目(XTZD20180401)。

摘　　要：目的探讨肥胖儿童肺通气功能特征及其与多种代谢指标的相关性。方法采用横断面研究方法,收集2019年1月-2022年12月于北京积水潭医院儿科就诊的肥胖儿童221例,年龄在6-14岁,测量身高、体重,空腹采集静脉血,完善肺通气功能检测,对比分析不同肥胖程度儿童各代谢指标及肺功能特征,并通过Pearson或Spearman相关分析研究各代谢指标与肺功能的相关性。结果221例肥胖儿童中,男性128例(57.9%),女性93例(42.1%),平均年龄(9.42±1.84)岁。重度肥胖组儿童糖化血红蛋白、空腹胰岛素、谷丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、尿酸、甘油三酯、低密度脂蛋白胆固醇、收缩压、舒张压均高于轻中度肥胖组儿童(P均<0.05),高密度脂蛋白胆固醇含量明显低于轻中度肥胖组(t=6.165,P<0.01)。轻中度肥胖组儿童各项肺功能指标普遍优于重度肥胖儿童,轻中度肥胖组FEV_(1)/FVC、FEV_(1)/FVC%高于重度肥胖组(t=2.052、2.001,P<0.05),FVC低于重度肥胖组(t=-2.733,P<0.01)。相关分析显示,FEV_(1)、FVC与碱性磷酸酶成负相关(P<0.05),PEF、FEF_(25%)与25-羟维生素D含量成正相关(P<0.05),FEV_(1)/FVC、FEV_(1)/FVC%、FEF_(50%)、FEF_(25%)均与糖化血红蛋白及空腹胰岛素水平成负相关(P<0.05),MMEF与糖化血红蛋白成负相关(P<0.05),FEF_(25%)与高密度脂蛋白胆固醇成正相关(P<0.05),与收缩压成负相关(P<0.05)。结论儿童肥胖导致肺功能下降及多种代谢紊乱,部分代谢指标与肺功能具有相关性,早期综合管理监测代谢指标对预防肺功能下降具有一定意义。Objective To investigate the relationship between pulmonary function and metabolic indexes in obese children.Methods For this cross-sectional study,A total of 221 obese children aged 6-14 years from January 2019 to December 2022 in the outpatient department of Beijing Jishuitan Hospital were collected.Height and weight were measured,venous blood was collected,and pulmonary ventilation function tests were performed to compare the metabolic indexes and pulmonary function characteristics of children with different obesity grades,and to explore the correlation between metabolic indexes and pulmonary function by Pearson or Spearman correlation analysis.Results Among the 221 obese children,128(57.9%)were male and 93(42.1%)were female,with an average age of(9.42±1.84)years.The glycosylated hemoglobin(HbA1c),fasting insulin(FINS),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum uric acid(sUA),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),systolic blood pressure(SBP),diastolic blood pressure(DBP)of children in the severe obesity group were higher than those in the mild-to-moderate(P<0.05),but the high-density lipoprotein cholesterol(HDL-Cs)was significantly lower(t=6.165,P<0.01).The pulmonary function in the mild to moderate obesity group was generally better than those in the severe.FEV_(1)/FVC and FEV_(1)/FVC% in the former group were higher than the latter(t=2.052、2.001,P<0.05),but FVC was lower(t=-2.733,P<0.01).Correlation analysis showed that FEV_(1) and FVC were negatively correlated with alkaline phosphatase(ALP)(P<0.05).PEF and FEF_(25%) were positively correlated with 25-hydroxyvitamin D[25(OH)D](P<0.05).FEV_(1)/FVC,FEV_(1)/FVC%,FEF_(50%) and FEF_(25%) were negatively correlated with HbA1c and FINS(P<0.05).MMEF was negatively correlated with HbA1c(P<0.05).FEF_(25%) was positively correlated with HDL-C(P<0.05)and negatively correlated with SBP(P<0.05).Conclusion Childhood Obesity leads to a decline in lung function and a variety of metabolic disorders.Some metabolic indicators a

关 键 词：肥胖 儿童 肺功能 代谢 

分 类 号：R723.14[医药卫生—儿科]