哮喘与女性夜尿症的相关性:2005—2018年NHANES数据分析  

Correlation between asthma and nocturia in women:an analysis based on NHANES database from 2005 to 2018

作　　者：杨春晓 杨林波 刘明[2] 文永安 李旭东[3] YANG Chunxiao;YANG Linbo;LIU Ming;WEN Yongan;LI Xudong(School of Medicine,Xizang Minzu University,Xianyang 712082;Department of Urology,Beijing Hospital,Beijing 100730;Department of Urology,The First Affiliated Hospital of Xi an Jiaotong University,Xi an 710061,China)

机构地区：[1]西藏民族大学医学院,陕西咸阳712082 [2]北京医院泌尿外科,北京100730 [3]西安交通大学第一附属医院泌尿外科,陕西西安710061

出　　处：《现代泌尿外科杂志》2025年第2期118-121,142,共5页Journal of Modern Urology

基　　金：国家自然科学基金重点项目(No.2022YFC3602900)。

摘　　要：目的基于2005—2018年美国国家健康与营养检查调查(NHANES)数据库分析哮喘与女性夜尿症的关系,为女性夜尿症的防治提供参考。方法筛选2005—2018年NHANES数据库中年龄≥20岁且患有夜尿症或哮喘的女性受访者,排除同时患有糖尿病、脑卒中及阻塞性睡眠呼吸及暂停综合征的受访者。采用复杂抽样设计进行加权分析,通过单因素分析、倾向性评分匹配(PSM)及多因素逻辑回归模型评估哮喘与女性夜尿症的相关性。结果本研究共筛选了14718例受访者,其中1426例(9.7%)被诊断为哮喘,4664例(31.7%)被诊断为夜尿症。单因素分析显示,哮喘与夜尿症间存在相关性(χ^(2)=39.846,P<0.01),年龄、身体质量指数(BMI)、吸烟及种族与夜尿症间也存在相关性(P<0.01)。多因素逻辑回归分析显示,PSM匹配前年龄、BMI、吸烟、种族及哮喘与夜尿症的发生风险有相关性(P<0.05)。为消除混杂偏倚,通过PSM匹配后广义线性混合模型分析显示,哮喘患者发生夜尿症的风险依然较高(OR=1.540,95%CI:1.320~1.800,P<0.01)。结论哮喘与女性夜尿症具有相关性,可能是女性夜尿症的重要风险因素。Objective To analyze the relationship between asthma and nocturia in women based on the National Health and Nutrition Examination Survey(NHANES)database from 2005 to 2018,so as to provide reference for the prevention and treatment of female nocturia.Methods Female respondents aged≥20 years with nocturia or asthma were selected from the 2005-2018 NHANES database.Those with both diabetes stroke and obstructive sleep apnea syndrome were excluded.A weighted analysis was conducted using a complex sampling design.The association between asthma and nocturia in women was evaluated with univariate analysis,propensity score matching(PSM),and multivariate logistic regression models.Results A total of 14718 respondents were selected,of whom 1426(9.7%)were diagnosed with asthma,and 4664(31.7%)with nocturia.There is a significant correlation between asthma and nocturia(χ^(2)=39.846,P<0.01).Age,body mass index(BMI),smoking and race were also associated with nocturia(P<0.01).Multivariate logistic regression analysis showed that,the age,BMI,smoking,race and asthma were correlated with the risk of nocturia,before PSM matching(P<0.05).To eliminate confounding bias,PSM was applied,and generalized linear mixed model analysis after matching showed that the risk of nocturia remained high in asthma patients(OR=1.540,95%CI:1.320-1.800,P<0.01).Conclusion Asthma is associated with nocturia in women,indicating that it may be an important risk factor for female nocturia.

关 键 词：哮喘 女性 夜尿症 美国国家健康与营养检查调查 逻辑回归 复杂抽样设计 

分 类 号：R691.9[医药卫生—泌尿科学]