球囊支架对吻技术和拘禁导丝技术在冠状动脉左前降支-对角支真性分叉病变患者中应用的单中心研究  

Clinical Efficacy of Balloon Stent Kissing Technique and Jailing Wire Technique in Patients With True Bifurcation Lesions of the Left Anterior Descending Branch-diagonal Branch of the Coronary Artery

作　　者：王硕 李柳[2] 刘国楹 随永刚[4] 武如冰 米杰 WANG Shuo;LI Liu;LIU Guoying;SUI Yonggang;WU Rubing;MI Jie(Department of Cardiology,Shijiazhuang People's Hospital,Shijiazhuang 050031,China;Department of Cardiology,Hebei Medical University First Hospital,Shijiazhuang 050011,China;Department of Cardiology,Huanghua People's Hospital,Huanghua 061100,China;Coronary Heart Disease Center,National Center for Cardiovascular Diseases and Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China)

机构地区：[1]石家庄市人民医院心内科,石家庄050031 [2]河北医科大学第一医院心内科,石家庄050011 [3]黄骅市人民医院心内科,黄骅061100 [4]中国医学科学院北京协和医学院国家心血管病中心阜外医院冠心病中心,北京100037

出　　处：《中国循环杂志》2025年第2期131-137,共7页Chinese Circulation Journal

基　　金：河北省卫生健康委员会重点科技研究计划(20240119);河北省医学科学研究重点课题计划(20160235)。

摘　　要：目的:探讨球囊支架对吻技术(BSKT)和拘禁导丝技术(JWT)在冠状动脉左前降支-对角支真性分叉病变患者中应用的疗效。方法:连续性入选2022年1月至2024年1月在石家庄市人民医院心内科住院的203例伴左前降支-对角支真性分叉病变的不稳定性心绞痛患者,所有患者采用BSKT或JWT术式进行治疗并完成6个月随访。根据住院号单双号分组,其中单号入组BSKT组(n=107),双号入组JWT组(n=96)。观察两种术式的安全性、有效性和心肌灌注指标。结果:BSKT组和JWT组术后即刻最小管腔面积、术后6个月加拿大心血管学会心绞痛分级、术后6个月静息+负荷心肌灌注总评分、静息+负荷心肌缺血总节段数、异常心肌灌注范围均显著优于术前,差异均有统计学意义(P均<0.05)。BSKT组支架置入即刻成功87例(81.3%),JWT组64例(66.7%),BSKT组显著优于JWT组;BSKT组术后1 d心肌肌钙蛋白I[(0.22±0.13)ng/ml vs.(0.45±0.27)ng/ml,P<0.001]、肌酸激酶同工酶[(35.24±13.15)U/L vs.(42.39±21.66)U/L,P=0.004]、B型利钠肽[(133.52±25.62)pg/ml vs.(167.22±22.04)pg/ml,P<0.001]均低于JWT组;术后6个月BSKT组的负荷心肌缺血总节段数[(3.23±1.54)节vs.(3.87±1.62)节,P=0.004]、负荷心肌灌注总评分[(4.18±2.21)分vs.(4.97±2.96)分,P=0.031]、异常心肌灌注范围[(7.04±3.27)%vs.(8.24±3.69)%,P=0.014]均低于JWT组,差异均有统计学意义。结论:BSKT和JWT两种术式均可显著改善左前降支-对角支真性分叉病变患者的心功能、心肌损伤和心肌灌注,BSKT术式对分支血管的保护作用较JWT术式更充分。Objectives:To explore the therapeutic efficacy of balloon stent kissing technique(BSKT)and jailing wire technique(JWT)in patients with true bifurcation lesions of the left anterior descending branch-diagonal branch of the coronary artery,and to observe the impact of these two interventional procedures on the lumen area,angina symptoms,cardiac function,myocardial injury,and myocardial perfusion of patients.Methods:A retrospective analysis was conducted in 203 patients with true bifurcation lesions of the left anterior descending branch-diagonal branch who underwent BSKT and JWT procedures and completed a 6-month follow-up in the Department of Cardiovascular Medicine at Shijiazhuang People's Hospital from January 2022 to January 2024.Patients were randomly assigned to the BSKT group(n=107)or the JWT group(n=96).The safety,efficacy,and myocardial perfusion indicators of the two groups were compared.Results:The minimum lumen area measured by intravascular ultrasound immediately after procedure,the Canadian Cardiovascular Society angina classification at 6 months post-intervention,the total score of resting+stress myocardial perfusion at 6 months post-intervention,the total number of segments with resting+stress myocardial ischemia,and the abnormal myocardial perfusion area in both the BSKT group and JWT group were significantly improved compared to baseline values(all P<0.05).In the BSKT group,87 cases(81.3%)achieved immediate success in stent placement,whereas in the JWT group,64 cases(66.7%)achieved immediate success in stent placement.The BSKT group significantly outperformed the JWT group.In terms of the myocardial injury and cardiac function indicators assessed on postoperative day 1,the cardiac troponin I level([0.22±0.13]ng/ml vs.[0.45±0.27]ng/ml,P<0.001),creatine kinase MB([35.24±13.15]U/L vs.[42.39±21.66]U/L,P=0.004),and B-type natriuretic peptide([133.52±25.62]pg/ml vs.[167.22±22.04]pg/ml,P<0.001)were all significantly lower in the BSKT group than in the JWT group.In terms of the myocardial perfusion

关 键 词：球囊支架对吻技术 拘禁导丝技术 左前降支-对角支真性分叉病变 动态单光子发射计算机断层扫描 

分 类 号：R541.4[医药卫生—心血管疾病]