钙蛋白酶在动脉粥样硬化中的作用及研究进展  

Research Progress on the Function of Calpain in Atherosclerosis

作　　者：张嘉祺 王茜婷[1] 陈夏欢[1] 刘梅林[1] ZHANG Jiaqi;WANG Xiting;CHEN Xiahuan;LIU Meilin(Department of Geriatrics,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院老年病内科,北京100034

出　　处：《中国循环杂志》2025年第2期203-208,共6页Chinese Circulation Journal

基　　金：北大百度基金资助项目(2019BD019);北京大学第一医院高质量临床研究专项(2023HQ04)。

摘　　要：动脉粥样硬化是威胁人类健康的主要疾病,可导致急性冠状动脉综合征、心肌梗死、脑卒中等疾病。动脉粥样硬化的发生与进展是一种慢性炎症性过程,与多种细胞的生物学活动相关。钙蛋白酶是Ca2+依赖性细胞内半胱氨酸蛋白酶,通过限制性催化蛋白水解调控多种底物,参与内皮损伤、炎症反应、脂质代谢等病理生理过程,在动脉粥样硬化的发生与进展中发挥着重要作用。本文综述了钙蛋白酶在动脉粥样硬化中的作用以及最新研究进展,为临床实现动脉粥样硬化个体化与精准化防治提供新思路。Atherosclerosis is a severe disease threatening human health,leading to tremendous consequences such as acute coronary syndrome,myocardial infarction,and stroke.The onset and progression of atherosclerosis are attributed to a chronic inflammatory process,closely associated with the biological activities of various cells.Calpain,a Ca2+-dependent cysteine protease within cells,plays a pivotal role in this context by regulating a plethora of substrates through restricted catalysis of protein hydrolysis,thereby participating in pathological and physiological processes including endothelial damage,inflammatory response,and lipid metabolism.This review summarizes the role of calpain in the development of atherosclerosis and the latest research progress in the application of calpain inhibitors for treatment of atherosclerosis,offering new insights for the clinical realization of personalized and precise treatment of atherosclerosis.

关 键 词：动脉粥样硬化 钙蛋白酶 炎症 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]