运动模拟保护大脑健康的神经化学分子机制研究进展  

Research Progress on the Neurochemical Molecules Mechanisms of Exercise Mimetics for Brain Health Protection

作　　者：李科[1] 杨昕 刘冉 赵旭东 王华林 毛兰群 侯莉娟[1] LI Ke;YANG Xin;LIU Ran;ZHAO Xudong;WANG Hualin;MAO Lanqun;HOU Lijuan(Beijing Normal University,Beijing 100875,China.)

机构地区：[1]北京师范大学,北京100875

出　　处：《中国体育科技》2025年第2期49-62,共14页China Sport Science and Technology

基　　金：国家自然科学基金重点项目(22134002)。

摘　　要：运动是保护大脑健康、延缓衰老和治疗中枢神经系统疾病重要的非药物疗法。运动模拟是在解析运动保护大脑健康神经化学分子机制的基础上,设计新型中枢神经系统治疗药物来模拟运动效果的新型治疗策略,旨在实现运动效应的转移与应用,使得无法进行运动的人群也能够从运动中获益。本文对运动模拟保护大脑健康的神经化学分子机制研究进展进行综述,提出寻找保护大脑健康的运动模拟分子靶点的新方法——脑神经活体原位电化学分析,以及增强运动模拟效应的新策略——高精准药物递送。Exercise is a critical non-pharmacological intervention for protecting brain health,delaying aging and treating central nervous system diseases.Exercise mimetics as a novel therapeutic strategy based on the molecular mechanisms of exercise to protect brain health,and explore innovative therapeutic drugs for central nervous system to mimic or enhance the effects of exercise,so that people who cannot do exercise can also benefit from it.This study reviews the research progress on neurochemical mechanisms of exercise mimetics to protect brain health,and proposes a novel method for the identification of molecular targets of exercise mimetics for brain health protection—in vivo electrochemical analysis of brain neurochemistry,and a strategy to optimize the efficacy of exercise mimetics—high-precision drug delivery.

关 键 词：运动模拟 大脑健康 脑神经活体原位电化学分析 药物递送 

分 类 号：G804.7[文化科学—运动人体科学]