生物力学因素调控动脉粥样硬化斑块内血管新生的研究进展  

Advance in biomechanical factors regulating angiogenesis in atherosclerotic plaques

作　　者：彭成秀 陈含笑 曾语涵 冯宇婧 李宇灏 沈阳[1] PENG Chengxiu;CHEN Hanxiao;ZENG Yuhan;FENG Yujing;LI Yuhao;SHEN Yang(Biomedical Engineering Research Laboratory,West China School of Basic Medicine and Forensic Medicine,Sichuan University,Chengdu,Sichuan 610041,China;School of Chemical Engineering,Sichuan University,Chengdu,Sichuan 610065,China)

机构地区：[1]四川大学华西基础医学与法医学院生物医学工程研究室,四川省成都市610041 [2]四川大学化学工程学院,四川省成都市610065

出　　处：《中国动脉硬化杂志》2025年第2期102-107,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(32071312、32371370)。

摘　　要：动脉粥样硬化斑块内新生血管对斑块的稳定具有决定性作用。流体剪切力、斑块结构应力和基质刚度所构成的力学微环境是介导斑块内血管生成的重要生物力学因素。血管内皮细胞响应力学信号,通过力-化学信号转导机制,参与斑块内血管生成。文章总结了力学因素调控斑块内血管新生的机制,为动脉粥样硬化的防治提供新的治疗策略。Angiogenesis within atherosclerotic plaques is a critical determinant of plaque stability.The biomechanical microenvironment,consisting of fluid shear force,plaque structural stress,and matrix stiffness,serves as significant factors in mediating plaque angiogenesis.Endothelial cells respond to mechanical signals and participate in plaques neovascularization through force chemical signal transduction mechanisms.This review provides an overview of the mechanisms by which mechanical factors regulate angiogenesis within plaques and offers a novel therapeutic approach for the prevention and treatment of atherosclerosis.

关 键 词：动脉粥样硬化斑块 血管新生 力学微环境 

分 类 号：R5[医药卫生—内科学] R363[医药卫生—临床医学]