lncRNA介导的ceRNA调控网络在动脉粥样硬化相关内皮功能障碍中的研究进展  

The emerging role of lncRNA-mediated ceRNA regulatory networks in atherosclerosis-associated endothelial dysfunction

作　　者：骆金文 刘敏 李敏[1] 于燕乔 史大卓[1] 马晓娟[4] LUO Jinwen;LIU Min;LI Min;YU Yanqiao;SHI Dazhuo;MA Xiaojuan(Cardiovascular Disease Research Center of Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100091,China;Cardiovascular Department of Hangzhou Red Cross Hospital,Hangzhou,Zhejiang 310009,China;Xiyuan Hospital,School of Clinical Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Health Research Center of Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院心血管病研究中心,北京100091 [2]杭州市红十字会医院心血管内科,浙江省杭州市310009 [3]北京中医药大学临床医学院西苑医院,北京100029 [4]中国中医科学院西苑医院保健研究中心,北京100091

出　　处：《中国动脉硬化杂志》2025年第2期169-177,共9页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(82174214、82074418);中国中医科学院科技创新工程重大攻关项目(CI2021A00911)。

摘　　要：内皮功能障碍是动脉粥样硬化(As)发生发展的一个关键因素。全面了解内皮功能障碍机制可为防治As提供新的视角。近年来,基因组和转录组技术的进步促进了研究者深入地探索内皮功能障碍的分子机制。研究发现,长链非编码RNA(lncRNA)介导的竞争性内源RNA(ceRNA)调控网络,在内皮功能障碍中发挥着重要作用。lncRNA充当微小RNA(miRNA)的“分子海绵”,通过与miRNA结合,阻断miRNA对下游靶基因信使RNA(mRNA)转录后的抑制作用,从而调节内皮细胞(EC)的功能和表型转换。lncRNA/miRNA/mRNA之间的相互作用广泛参与EC的炎症反应、凋亡、自噬及新生血管形成和内皮-间质转化(EndMT)等病理生理的调节,表明其可能成为As潜在治疗靶点。Endothelial dysfunction is a pivotal contributor to atherosclerosis(As)pathogenesis.A comprehensive understanding of the mechanisms of endothelial dysfunction would provide novel insights into effective treatment of As.Recent advances in genome and transcripome technology have enabled researchers to further explore the molecular mechanisms of endothelial dysfunction.It has been found that the regulatory network of competitive endogenous RNA(ceRNA)mediated by long non-coding RNA(lncRNA)plays a key role in endothelial dysfunction.lncRNA acts as a“molecular sponge”for microRNA(miRNA)to block the post-transcriptional repression of miRNA on downstream target gene messenger RNA(mRNA)by binding to miRNA,thereby regulating the function and phenotypic conversion of endothelial cell(EC)lncRNA-miRNA-mRNA interactions are widely involved in play an essential role EC inflammatory responses,apoptosis,autophagy,angiogenesis,and endothelial-mesenchymal transition(EndMT).Which suggests that it may be a potential therapeutic targets for As.

关 键 词：动脉粥样硬化 内皮细胞 长链非编码RNA 微小RNA 

分 类 号：R5[医药卫生—内科学]