沙眼衣原体和淋病奈瑟菌及解脲支原体在宫颈上皮内瘤变筛查中的应用价值  

Application value of Chlamydia trachomatis,Neisseria gonorrhoeae and Ureaplasma urealyticum in cervical intraepithelial neoplasia screening

作　　者：林震 李阳 Lin Zhen;Li Yang(Department of Clinical Laboratory,Zhengzhou Central Hospital,Zhengzhou,Henan 450006,China)

机构地区：[1]郑州市中心医院检验科,河南郑州450000

出　　处：《感染、炎症、修复》2025年第1期22-24,29,共4页Infection Inflammation Repair

基　　金：河南省科技攻关项目(24B320021)。

摘　　要：目的:分析宫颈分泌物中沙眼衣原体(CT)、淋病奈瑟菌(NG)及解脲支原体(UU)在宫颈上皮内瘤变(CIN)筛查中的应用价值。方法:选取2021年8月至2023年7月郑州市中心医院经阴道镜直视下取宫颈组织活检确诊为CIN患者159例作为观察组,另选取同期因多个性伴侣、早年性行为、吸烟、免疫系统功能低下、长期口服避孕药、人乳头瘤病毒感染史等因素就诊且经病理证实宫颈组织无病变的就诊者157例作为对照组。以病理检查为“金标准”,比较两组CT、NG及UU表达情况;比较CIN不同分级患者的CT、NG、UU单一及联合表达情况;分析CT、NG、UU单一及联合诊断CIN的诊断效能与病理活检的一致性。结果:观察组宫颈组织中CT、NG与UU阳性表达率均高于对照组(P<0.05);CT阳性率比较:CINⅠ级<CINⅡ级<CINⅢ级(P<0.05);NG阳性率比较:CINⅠ级<CINⅡ级<CINⅢ级(P>0.05),UU阳性率比较:CINⅠ级<CINⅡ级<CINⅢ级(P>0.05),CT阳性+NG阳性+UU阳性的阳性率比较:CINⅠ级<CINⅡ级<CINⅢ级(P>0.05);CT、NG及UU联合诊断CIN与病理活检的一致性为0.907,均高于CT、NG及UU单一检测的一致性。结论:宫颈分泌物中CT、NG及UU检测在CIN筛查中有一定应用价值,可为CIN早期诊断提供重要参考依据。Objective:To analyze the application value of Chlamydia trachomatis(CT),Neisseria gonorrhoeae(NG)and Ureaplasma urealyticum(UU)in cervical secretions screening for cervical intraepithelial neoplasia grade(CIN).Methods:From August 2021 to July 2023,159 patients diagnosed with CIN by cervical tissue biopsy under colposcopy in Zhengzhou Central Hospital were selected as the observation group.In addition,157 patients with multiple sexual partners,early sexual behavior,smoking,low immune system function,long-term oral contraceptives,history of human papilloma virus(HPV)infection and other factors were selected as the control group.Pathological examination was used as the"gold standard"to evaluate the expression of CT,NG and UU between the two groups.The single and combined expression of CT,NG and UU in CIN with different grades were compared.The diagnostic efficacy and consistency of CT,NG and UU in the diagnosis of CIN were analyzed.Results:The positive expressions of CT,NG and UU in cervical tissues of observation group were higher than those in the control group(P<0.05).CT positive rate comparison:CINⅠ<CINⅡ<CINⅢ(P<0.05);NG positive rate comparison:CINⅠ<CINⅡ<CINⅢ(P>0.05);UU positive rate comparison:CINⅠ<CINⅡ<CINⅢ(P>0.05),CT positive+NG positive+UU positive rate comparison:CINⅠ<CINⅡ<CINⅢ(P>0.05);The consistency between CT,NG and UU combined diagnosis of CIN and pathological biopsy was 0.907,which was higher than that of CT,NG and UU single detection,Conclusions:The detection of CT,NG and UU in cervical secretions has certain application value in the screening of CIN,and can provide an important reference for the early diagnosis of CIN.

关 键 词：沙眼衣原体 淋病奈瑟菌 解脲支原体 宫颈上皮内瘤变 

分 类 号：R446.5[医药卫生—诊断学] R446.6[医药卫生—临床医学]