血清GDF-15、SDF-1和CXCL16水平与冠状动脉粥样硬化性心脏病患者冠状动脉狭窄的关系研究  

Relationship between levels of serum GDF-15,SDF-1 and CXCL16 and coronary artery stenosis in patients with coronary heartdisease

作　　者：赵文心 祁新坤 李雅欣 Zhao Wenxin;Qi Xinkun;Li Yaxin(Department of Clinical Laboratory,Fuwaihua Central Vascular Disease Hospital,Zhengzhou,Henan 450000,China)

机构地区：[1]阜外华中心血管病医院检验科,河南郑州450000

出　　处：《感染、炎症、修复》2025年第1期49-52,共4页Infection Inflammation Repair

摘　　要：目的:探讨血清生长分化因子-15(GDF-15)、基质细胞衍生因子-1(SDF-1)、CXC趋化因子配体16(CXCL16)水平与冠状动脉粥样硬化性心脏病(CHD)患者冠状动脉狭窄的关系。方法:选取阜外华中心血管病医院2021年7月至2023年6月收治的136例CHD患者为研究对象设为CHD组,另选同期120例健康体检者设为健康组,比较两组一般临床资料及血清GDF-15、SDF-1、CXCL16水平,根据Gensini评分将CHD组分为轻度狭窄组、中度狭窄组、重度狭窄组,比较不同狭窄程度下CHD患者的血清GDF-15、SDF-1、CXCL16水平,Pearson相关性分析方法分析Gensini评分与血清GDF-15、SDF-1、CXCL16的关系。结果:CHD组合并高血压、高血脂比例显著高于健康组(P<0.05),血清总胆固醇、甘油三酯、同型半胱氨酸、肌钙蛋白水平、左心室舒张末期内径显著高于健康组(P<0.05),高密度脂蛋白胆固醇、左心室射血分数显著低于健康组(P<0.05);血清GDF-15、SDF-1、CXCL16水平:健康组<CHD组,轻度组<中度组<重度组(P<0.05);Gensini评分与血清GDF-15、SDF-1、CXCL16均呈显著正相关(P<0.05)。结论:GDF-15、SDF-1、CXCL16水平与CHD患者冠状动脉狭窄程度存在一定的相关性,可用于CHD临床诊断及治疗的辅助性检测。Objective:To explore the relationship between levels of serum growth differentiation factor-15(GDF-15),stromal cell derived factor-1(SDF-1)and CXC chemokine ligand 16(CXCL16)and coronary artery stenosis in patients with coronary heart disease(CHD).Methods:A total of 136 patients with CHD in Fuwaihua Central Vascular Disease Hospital from July 2021 to June 2023 were selected as CHD group,and 120 healthy subjects who underwent physical examination during the same period were included in the healthy group.The general clinical data and serum levels of GDF-15,SDF-1 and CXCL16 were compared between the two groups,and the patients in CHD group were divided into mild stenosis group,moderate stenosis group and severe stenosis group according to the Gensini score.The levels of serum GDF-15,SDF-1 and CXCL16 were compared among patients with CHD of different stenosis degrees,and the relationship between Gensini score and serum GDF-15,SDF-1 and CXCL16 was analyzed by Pearson correlation analysis.Results:The proportion of hypertension and hyperlipidemia in the CHD group was significantly higher than that in healthy group(P<0.05);serum triglyceride TG,total cholesterol(TC),homocysteine(Hcy),troponin levels and left ventricular end diastolic dimension(LVEDD)value were significantly higher than those in healthy group(P<0.05).High density lipoprotein cholesterol(HDL-C),Left ventricular ejection fraction(LVEF)value were significantly lower than those in the healthy group(P<0.05).The levels of serum GDF-15,SDF-1 and CXCL16:Healty group<CHD group,mild group<moderate group<severe group(P<0.05).Gensini score was significantly positively correlated with serum GDF-15,SDF-1 and CXCL16(P<0.05).Conclusions:The levels of GDF-15,SDF-1,and CXCL16 are correlated with the degree of coronary artery stenosis in CHD patients,which can be used as auxiliary detection indicators for clinical diagnosis and treatment of CHD.

关 键 词：生长分化因子-15 基质细胞衍生因子-1 CXC趋化因子配体16 冠状动脉粥样硬化性心脏病 动脉狭窄 

分 类 号：R543.1[医药卫生—心血管疾病]