儿童急性良性肌炎实验室指标变化及临床意义  

Changes and Clinical Significance of Laboratory Indicators of Acute Benign Myositis

作　　者：王孟迪 李静 WANG Mengdi;LI Jing(Department of Pediatrics,the First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121000 China)

机构地区：[1]锦州医科大学附属第一医院儿科,辽宁锦州121000

出　　处：《锦州医科大学学报》2025年第1期70-74,共5页Journal of Jinzhou Medical University

基　　金：辽宁省科学技术基金项目,项目编号:SCE168EN。

摘　　要：目的通过研究良性肌炎患儿相关实验室指标的变化特点,探讨其在肌炎发生、发展过程中的意义和价值。方法选取2022年10月至2023年3月在锦州医科大学附属第一医院儿科住院的29例急性良性肌炎患儿作为研究对象。这些患儿被纳入病例组,其中男性19例、女性10例,年龄3~13岁,平均年龄4岁。为进行对比分析,另外选取29例健康儿童作为对照组,其中男性13例、女性16例,年龄1~12岁,平均年龄3岁。整理两组儿童的临床和实验室资料,如性别、年龄、身高、体重、体重指数(body mass index,BMI)、肌酸激酶(creatine kinase,CK)、肌红蛋白(myoglobin,Mb)和肌酸激酶同工酶(creatine kinase isoenzyme MB,CK-MB)等重要指标。为确保数据准确和可靠,使用SPSS软件进行统计学分析。结果在对两组患儿的一般资料进行分析时,并未观察到统计学上存在明显差异。在29例病例组患儿中,与健康对照组相比,心肌酶谱检测结果显示,在良性肌炎肌痛症状出现后的24 h内,CK和Mb的浓度明显升高,均超过正常水平的10倍。随后,这些酶的浓度逐渐下降。CK-MB的浓度与对照组相比,浓度仍然高于正常水平,差异无统计学意义(P>0.05)。分析灵敏度数据表明,发病后24 h内,Mb和CK的浓度变化差异无统计学意义。与CK-MB的浓度变化相比,差异有统计学意义(P<0.001)。发病第4天,Mb和CK的浓度变化差异有统计学意义(P<0.05)。结论良性肌炎的成因可能涉及多种病原体,包括但不限于流感病毒、EB病毒、支原体和细菌感染。主要临床表现是不同程度肌肉疼痛,同时伴有肌酸激酶和肌红蛋白水平明显升高。通过早期检测和持续监测这两种生化指标的变化,可以对肌炎的诊断和病情进展提供预警。Objective To explore the significance and value of laboratory indexes in the occurrence and development of benign myositis through studying the changes of relevant laboratory indexes in children with benign myositis.Methods A total of 29 children with acute benign myositis who were hospitalized in the Department of Pediatrics of the First Affiliated Hospital of Jinzhou Medical University from October 2022 to March 2023 were selected as the study objects.These children were included in the case group,including 19 males and 10 females,aged from 3 to 13 years,with an average age of 4 years.For comparative analysis,another 29 healthy children were selected as the control group,including male(13 cases)and 16 female(16 cases),aged from 1 to 12 years old with an average age of 3 years old.Clinical and laboratory data,such as sex,age,height,weight,body mass index(BMI),creatine kinase(CK),myoglobin(Mb)and creatine kinase isoenzyme MB(CK-MB)were collected for the two groups of children.To ensure the accuracy and reliability of the data,SPSS software was used for statistical analysis.Results No statistical difference was found in the analysis of general data between the two groups.Compared with the healthy control group,the myocardial enzymology test results of 29 cases showed that the concentrations of CK and Mb increased sharply within 24 h after the onset of benign myalgia symptoms,both of which were more than 10 times the normal level.Subsequently,the concentration of these enzymes gradually fell back.CK and Mb concentrations remained higher than normal,and there was no significant difference(P>0.05).Analysis of sensitivity data showed that there was no statistically significant difference between Mb and CK concentrations within 24 h after onset.Compared with the concentration of CK-MB,the difference was statistically significant(P<0.001).On the 4th day of onset,the concentration changes of Mb and CK were statistically significant(P<0.05).Conclusion The occurrence of benign myositis can be attributed to a variety of pat

关 键 词：儿童急性良性肌炎 肌痛 肌酸激酶 肌红蛋白 

分 类 号：R726.8[医药卫生—儿科]