奥司他韦与帕拉米韦治疗流行性感冒并发热性惊厥儿童的效果对比  

Comparison of the Effect of Oseltamivir and Peramivir in the Treatment of Influenza and Febrile Convulsion in Children

作　　者：李冰露 丁学星 王永霞[1] 马晓丹 LI Binglu;DING Xuexing;WANG Yongxia;MA Xiaodan(Department of Pediatrics,Anyang People′s Hospital,Anyang 455000 China)

机构地区：[1]安阳市人民医院儿科,河南安阳455000

出　　处：《锦州医科大学学报》2025年第1期109-112,F0003,共5页Journal of Jinzhou Medical University

基　　金：安阳市科技发展计划项目,项目编号:安科[2020]14号。

摘　　要：目的探讨流行性感冒并发热性惊厥患儿应用奥司他韦与帕拉米韦治疗的临床效果对比研究。方法将选自2020年2月至2024年2月在安阳市人民医院发热门诊确诊的70例流行性感冒并发热性惊厥患儿采用简单随机分组法划分为两组(观察组和对照组),每组各35例。对照组患儿给予奥司他韦口服用药,观察组患儿给予帕拉米韦注射给药,对比两组患者临床疗效、症状缓解时间和治疗后炎症因子水平和免疫球蛋白水平变化。结果观察组治疗有效率大于对照组(97.12%>82.86%)(P<0.05);观察组退热、咳嗽减轻、痰液减少、咽痛、头痛缓解时间低于对照组(P<0.05);治疗后,两组血清淀粉样蛋白A(serum amyloid A protein,SAA)、降钙素原(procalcitonin,PCT)、白介素6(interleukin 6,IL-6)水平均下降,且观察组低于对照组(P<0.05);治疗后,两组免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白G(immunoglobulin G,IgG)水平均上升,且观察组高于对照组(P<0.05);不良反应差异无统计学意义(11.43%vs 20.00%)(P>0.05)。结论对于流行性感冒病发热惊厥的治疗,帕拉米韦的临床疗效和症状缓解时间均优于对照组,且其对炎症因子和免疫球蛋白的调节作用也更好。Objective To investigate the clinical effect of oseltamivir and peramivir in children with influenza and febrile convulsion.Methods A total of 70 children with influenza and febrile convulsion diagnosed in the fever clinic of Anyang City People′s Hospital from February 2020 to February 2024 were divided into 2 groups(observation group and control group)by simple randomization method,with 35 cases in each group.The control group was given oseltamivir orally,and the observation group was given peramivir injection.The clinical efficacy,symptom remission time,and the changes of inflammatory factors and immunoglobulin levels after treatment were compared between the two groups.Results The treatment effective rate of the observation group was higher than that of the control group(97.12%>82.86%)(P<0.05);the defervescence,cough relief,reduction of phlegm,sore throat,and headache relief time in the observation group were lower than those in the control group(P<0.05);after treatment,the levels of serum amyloid A(SAA),procalcitonin(PCT),and interleukin 6(IL-6)in both groups decreased,and the observation group was lower than the control group(P<0.05);after treatment,the levels of immunoglobulin A(IgA),immunoglobulin M(IgM),and immunoglobulin G(IgG)in both groups increased,and the observation group was higher than the control group(P<0.05);there was no statistically significant difference in adverse reactions(11.43%vs 20.00%)(P>0.05).Conclusion For the treatment of influenza with febrile convulsion,the clinical efficacy and symptom relief time of peramivir are better than those of the control group,and it also has a better regulatory effect on inflammatory factors and immunoglobulins.

关 键 词：流行性感冒 发热性惊厥 奥司他韦 帕拉米韦 

分 类 号：R720.597[医药卫生—急诊医学]