抗结核药物引发的药物超敏反应综合征一例并文献复习  

A Case of Drug Hypersensitivity Syndrome Induced by Antituberculosis Drugs and Literature Review

作　　者：陈金玉 邓彬 陈蕾 CHEN Jin-yu;DENG Bin;CHEN Lei(Department of TuberculosisⅡPublic Health Clinical Center of Chengdu,Chengdu Sichuan 610066,China)

机构地区：[1]成都市公共卫生临床医疗中心结核病二科,四川成都610066

出　　处：《中华养生保健》2025年第3期172-176,共5页CHINESE HEALTH CARE

摘　　要：目的为加强对药物超敏反应综合征(DIHS)的认知,并提高抗结核药物引起DIHS的诊疗水平。方法回顾1例患者因抗结核药物所致DIHS的病情变化,结合DIHS专家共识和相关文献对患者的诊疗过程及结局进行分析。结果患者病程中出现持续高热、迟发性皮疹、全身多处淋巴结肿大、异常的血液结果、器官(肺、肝脏等)受损等特点,符合DIHS诊断标准。结论考虑诊断DIHS时,治疗关键是及时停用所有抗结核药物。轻症患者使用抗过敏药物对症治疗即可,重症患者可采用糖皮质激素治疗,目前无统一专家共识及指南,治疗过程中应权衡利弊使用。Objective To strengthen the understanding of drug hypersensitivity syndrome(DIHS)and improve the diagnosis and treatment of DIHS caused by anti-tuberculosis drugs.Methods The condition changes of a patient with DIHS caused by anti-tuberculosis drugs were reviewed,and the clinical symptoms,test indicators and disposal of the patient were analyzed in combination with the expert consensus of DIHS and related literature.Results The patient had persistent fever,delayed rash,multiple lymphadenopathy,hematological abnormalities,liver and other organ damage,which met the diagnostic criteria of DIHS.Conclusion When considering the diagnosis of DIHS,it is the key to stop all anti-tuberculosis drugs in time,mild patients can be treated with anti-allergic drugs,and severe patients can be treated with glucocorticoid,but there is no unifi ed consensus at present,and the advantages and disadvantages should be weighed.

关 键 词：肺结核 抗结核治疗 超敏综合征 

分 类 号：R521[医药卫生—内科学]