STING通路在心血管疾病中作用的研究进展  

Research progress of STING pathway in cardiovascular diseases

作　　者：简武 何璐[2] 屈洪涛[2] 吴建华 张瑶 Jian Wu;He Lu;Qu Hongtao;Wu Jianhua;Zhang Yao(Department of Inspection,Changde Hospital,Xiangya School of Medicine,Central South University,Changde 415000,China;Department of Neurosurgery,The First Affiliated Hospital of University of South China,Hengyang 421001,China)

机构地区：[1]中南大学湘雅医学院附属常德医院检验科,415000 [2]南华大学附属第一医院神经外科,衡阳421001

出　　处：《中国心血管杂志》2025年第1期106-111,共6页Chinese Journal of Cardiovascular Medicine

基　　金：湖南省自然科学基金青年基金项目(2022JJ40003);湖南省自然科学基金科卫联合项目(2021JJ70042);常德市科技创新指导性项目(2024ZD184、2024ZD219)。

摘　　要：环鸟苷酸-腺苷酸合酶和干扰素基因刺激因子(STING)在免疫应答中发挥关键作用。STING激活下游信号分子和炎症因子,诱发器官功能障碍,参与心血管疾病(CVD)等慢性炎症性疾病的发生发展。本文就STING途径与CVD的密切联系作一综述,为CVD靶向治疗提供新方向。Cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)and stimulator of interferon gene(STING)play key roles in the innate immune response.STING activates its downstream signaling molecules and inflammatory factors,leading to organ dysfunction,thereby participating the progression of chronic inflammatory disease like cardiovascular diseases(CVD),et al.This article reviews the close relationship between the STING pathway and CVD,offering a new direction for targeted therapy of CVD.

关 键 词：心血管疾病 干扰素基因刺激因子 环鸟苷酸-腺苷酸合酶 炎症 

分 类 号：R54[医药卫生—心血管疾病]