Apelin/APJ系统抑制线粒体通透性转换孔开放在防治冠状动脉微循环障碍中作用的研究进展  

Research progress on the treatment of coronary microvascular dysfunction by inhibiting the open of mitochondrial permeability transition pore through the Apelin/APJ system

作　　者：蒋虎刚 刘爱 唐演 刘凯 赵信科 李应东 Jiang Hugang;Liu Ai;Tang Yan;Liu Kai;Zhao Xinke;Li Yingdong(College of Integrated Traditional and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Cardiovascular Center,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中西医结合学院,兰州730000 [2]甘肃中医药大学附属医院心血管中心,兰州730000

出　　处：《中国心血管杂志》2025年第1期112-118,共7页Chinese Journal of Cardiovascular Medicine

基　　金：国家自然科学基金(82374279);甘肃省青年科技基金(23JRRA1217);2023年度“双一流”科研重点项目(GSSYLXM-05-ZXYJH-11)。

摘　　要：血管内皮细胞是冠状动脉微血管的结构基础,其分泌功能参与调节微循环的多种功能,而内皮细胞线粒体通透性转换孔(MPTP)开放可通过线粒体途径诱导细胞凋亡。Apelin/APJ系统是内皮细胞膜跨膜信号转导的重要靶点,其具有抗氧化、抑制细胞凋亡和促进血管生成等作用。因此,Apelin/APJ系统抑制MPTP开放是冠状动脉微循环障碍的潜在干预机制。Endothelial cells are the structural basis of coronary microvessels,and their secretory function is involved in regulating various functions of the microcirculation.The opening of the mitochondrial permeability transition pore(MPTP)in endothelial cells can induce cell apoptosis via the mitochondrial pathway.The Apelin/APJ system is an important target for transmembrane signal transduction in endothelial cells,which shows antioxidant,anti-apoptotic,and pro-angiogenic effects.Therefore,the inhibition of MPTP opening by the Apelin/APJ system is a potential interventional mechanism for coronary microvascular disease.

关 键 词：冠状动脉微循环障碍 Apelin/APJ系统 线粒体通透性转换孔 血管内皮细胞 

分 类 号：R543.3[医药卫生—心血管疾病]