基于数据挖掘对倪英群治疗痤疮湿热证的用药规律研究  

Study on the Medication Regularity of NI Yingqun in Treating the Damp-heat Syndrome of Acne Based on Data Mining

作　　者：叶蕾 方朝晖[2] 张喆 吴泽龙 倪英群[2] YE Lei;FANG Zhaohui;ZHANG Zhe;WU Zelong;NI Yingqun(The First Clinical Medical College of Anhui University of Chinese Medicine,Hefei 230038,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230038,China)

机构地区：[1]安徽中医药大学第一临床医学院,安徽合肥230038 [2]安徽中医药大学第一附属医院,安徽合肥230038

出　　处：《陕西中医药大学学报》2025年第2期79-84,共6页Journal of Shaanxi University of Chinese Medicine

基　　金：新安医学教育部重点实验室开放项目(2022XAYX06);安徽省医疗卫生重点专科建设项目(中医内分泌)(皖卫函[2021]273号);安徽省教育厅新时代育人质量工程项目(ahzyydx_tb4312);安徽省教学研究项目(2022jyxm882)。

摘　　要：目的运用数据挖掘技术探析倪英群主任医师治疗痤疮湿热证的用药规律。方法收集2021年1月—2023年11月倪师治疗痤疮湿热证的门诊处方数据,创建病历数据库,通过SPSS 25.0统计软件和SPSS Modeler 18.0软件进行关联规则分析和高频药物聚类分析,并对中药的频数、性味归经和功效进行统计。结果通过收集与整理,共纳入中药处方181首,涉及中药149味,使用频次前10的药物分别为薏苡仁、地肤子、牡丹皮、白芷、蒲公英、栀子、薄荷、生地黄、连翘、茯苓。四气以寒、温、平为主,五味以苦、甘、辛为主,主归肝经、肺经、脾经。关联规则得出使用频率最高的药对为“薏苡仁—白芷”“薏苡仁—栀子”和“薏苡仁—白芷+地肤子”,聚类分析得到5个结果。结论倪师认为痤疮湿热证病位主要在脾胃,与肝、肺、肾密切相关。治疗时应标本兼顾,在清热利湿基础上辨证施治,伴肺热明显者兼清泻肺热,伴肝气郁结者兼疏肝理气,伴脾肾亏虚者兼滋补脾肾。Objective To explore the medication pattern of Chief Physician NI Yingqun in treating acne damp-heat syndrome using data mining techniques.Methods A medical record database was created by collecting outpatient prescription data from January 2021 to November 2023 for the treatment of acne damp-heat syndrome by Master NI.SPSS 25.0 statistical software and SPSS Modeler 18.0 software were used to perform the association rule analysis and high-frequency drug clustering analysis.The frequency,nature,flavour,meridian and efficacy of the Chinese medicines were analysed and statistically reported.Results Through collection and collation,a total of 181 Chinese medicine prescriptions were included,comprising 149 flavours of herbal medicines,and the top 10 medicines in terms of frequency of use were Coix lacryma,Dioscorea alba,Mudanpi,Angelica dahurica,Dandelion,Gardenia jasminoides,Peppermint,Radix rehmanniae,Forsythia,and Poria.The medicinal properties were mainly cold,warm and mild,and the medicinal tastes were mainly bitter,sweet and pungent.The attribution of drugs was mainly based on the liver meridian,lung meridian and spleen meridian.The association rules yielded the most frequently used pairs as“Coix lacryma-Angelica dahurica”“Coix lacryma-Gardenia jasminoides”and“Coix lacryma-Angelica Dahurica+Dioscorea alba”,and cluster analysis yielded five results.Conclusion Master NI holds that the disease location of the damp-heat syndrome of acne is mainly in the spleen and stomach,and is closely related to the liver,lung and kidney.Treatment should take into account both the symptoms and the root cause.On the basis of clearing heat and removing dampness,different treatment methods are used for patients with different concomitant symptoms,such as clearing lung heat for those with dispersing lung heat,clearing liver Qi for those with liver Qi stagnation,and nourishing spleen and kidneys for those with deficiency of spleen and kidneys.

关 键 词：痤疮 湿热证 用药规律 数据挖掘 倪英群 

分 类 号：R261[医药卫生—中医外科学]