不同来源细胞外囊泡与骨关节炎研究进展  

Research progress in extracellular vesicles from different sources and osteoarthritis

作　　者：周晓杰 何大伟[2] 高焱 徐敏哲 施勤[3] 李翀[2] ZHOU Xiaojie;HE Dawei;GAO Yan;XU Minzhe;SHI Qin;LI Chong(Jiangsu University,Zhenjiang 212000,China;Kunshan Hospital Affiliated to Jiangsu University,Suzhou 215300,China;Department of Orthopedics,the First Affiliated Hospital of Soochow University,Medical College of Soochow University,Orthopedic Institute of Soochow University,Suzhou 215007,China)

机构地区：[1]江苏大学,江苏镇江212000 [2]江苏大学附属昆山医院,江苏苏州215300 [3]苏州大学医学部第一附属医院骨科,苏州大学医学院,苏州大学骨科研究所,江苏苏州215007

出　　处：《中国骨质疏松杂志》2025年第2期272-277,共6页Chinese Journal of Osteoporosis

基　　金：昆山市骨质疏松性骨折防治重点实验室项目(KZ2023005);2021年江苏省卫生健康委员会医学科研项目(Z2021026)。

摘　　要：骨关节炎(osteoarthritis,OA)是以关节软骨退变和骨骼结构改变为特征的退行性疾病,给患者和社会经济带来重大负担。目前,骨关节炎的治疗存在许多局限性,特别是缺少有效的早期诊断和治疗方法。干细胞已被证实可以促进软骨修复和治疗OA,但免疫排斥和致瘤性等问题限制了其广泛应用。细胞外囊泡(extracellular vesicies,EVs)作为一种无细胞治疗策略备受关注。因其低免疫原性和能够介导细胞间通讯的特性,被认为在OA的治疗中具有潜力。笔者综述了不同来源的EVs在OA发病、诊断和治疗中的研究进展。Osteoarthritis(OA)is a degenerative disease characterized by the degeneration of joint cartilage and alterations in bone structure,imposing significant burdens on patients and the socio-economic landscape.Currently,the treatment of osteoarthritis is hampered by numerous limitations,particularly the lack of effective early diagnostic and therapeutic approaches.Stem cells have been demonstrated to promote cartilage repair and to treat OA.However,issues such as immunogenicity and oncogenic potential restrict their widespread application.Extracellular vesicles(EVs),as a cell-free therapeutic strategy,have garnered considerable attention due to their low immunogenicity and ability to mediate intercellular communication,suggesting their potential in the treatment of OA.This article reviews the research progress in EVs from various sources in the pathogenesis,diagnosis,and treatment of OA,highlighting their emerging role and therapeutic promise.

关 键 词：骨关节炎 细胞外囊泡 软骨祖细胞 骨髓间充质干细胞 滑膜间充质干细胞 

分 类 号：R684.3[医药卫生—骨科学] R336[医药卫生—外科学]