无针注射胰岛素注射完成率和性能的实验研究  

Experimental study on injection completion rate and performance for needle-free insulin injection

作　　者：朱洋[1] 康灿[1] 蔡伟 黄超 ZHU Yang;KANG Can;CAI Wei;HUANG Chao(School of Energy and Power Engineering,Jiangsu University,Zhenjiang,Jiangsu 212013,P.R.China;Jiangsu Poke Medical Technology Co.,Ltd.,Taizhou,Jiangsu 225300,P.R.China;School of Medicine,Jiangsu University,Zhenjiang,Jiangsu 212013,P.R.China)

机构地区：[1]江苏大学能源与动力工程学院,江苏镇江212013 [2]江苏铂可医疗科技有限公司,江苏泰州225300 [3]江苏大学医学院,江苏镇江212013

出　　处：《生物医学工程学杂志》2025年第1期181-188,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(52311540154);镇江市社会发展指导性科技计划项目(FZ2022053)。

摘　　要：无针注射技术是一种利用高速微射流将药液递送进皮下指定部位的新型给药手段。尽管目前无针注射技术已在多个领域得到应用,但针对其药液扩散机制和注射性能的研究仍存在一定的不足。本研究旨在确定无针注射过程中的关键参数,并描述其对注射效果的影响。本文通过小鼠实验的方法,比较了不同注射条件下无针注射器的注射完成率和注射性能。结果表明,相比于其它注射参数,喷嘴直径对射流性能的影响更为明显。此外,注射完成率随喷嘴直径增大而增加,当喷嘴直径为0.14 mm和0.25 mm时,注射完成率分别为89.7%和95.8%。进而,通过对小鼠血糖变化率的分析发现,采用无针注射的方式进行胰岛素给药可以获得超过120 min的药效持续时间,优于传统针头注射方式。综上,本文所得结论可为气动无针注射器的优化设计和拓展应用提供重要参考依据。As a relatively novel technique for drug delivery,the needle-free injection technique is characterized by transporting the drug liquid to the designated subcutaneous position through a high-speed micro-jet.Although this technique has been applied in many fields,the research on its drug dispersion mechanism and injection performance is insufficient.The presented study aims to identify critical parameters during the injection process and describe their influence on the injection effect.The injection completion rate and performance of a needle-free injector under various operating conditions were compared based on mouse experiments.The results show that the nozzle diameter imposes a more significant influence on jet characteristics than other injection parameters.Moreover,the injection completion rate increases with the nozzle diameter.The nozzle diameters of 0.14 mm and 0.25 mm correspond to injection completion rates of 89.7%and 95.8%,respectively.Furthermore,by analyzing the rate of blood glucose change in the tested mice,it is found that insulin administration through the needle-free injection can achieve a drug effect duration longer than 120 min,which is better than that obtained using conventional needle-syringe technique.In summary,the obtained conclusions can provide an important reference for the optimal design and extending application of the air-powered needle-free injector.

关 键 词：无针注射器 小鼠 注射完成率 皮丘 胰岛素 

分 类 号：TH77[机械工程—仪器科学与技术]