抑郁症的脑磁图信号特征研究进展  

Research progress on the characteristics of magnetoencephalography signals in depression

作　　者：陈志远 黄永志 于海情 曹春燕[4] 许敏鹏(综述) 明东(审校)[1,2,3] CHEN Zhiyuan;HUANG Yongzhi;YU Haiqing;CAO Chunyan;XU Minpeng;MING Dong(Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin 300072,P.R.China;State Key Laboratory of Advanced Medical Materials and Devices,Tianjin University,Tianjin 300072,P.R.China;Haihe Laboratory of Brain-computer Interaction and Human-machine Integration,Tianjin 300392,P.R.China;Department of Neurosurgery,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,P.R.China)

机构地区：[1]天津大学医学工程与转化医学研究院,天津300072 [2]天津大学先进医用材料与医疗器械全国重点实验室,天津300072 [3]脑机交互与人机共融海河实验室,天津300392 [4]上海交通大学医学院附属瑞金医院神经外科,上海200025

出　　处：《生物医学工程学杂志》2025年第1期189-196,共8页Journal of Biomedical Engineering

基　　金：国家自然科学基金(82472101)。

摘　　要：抑郁症是一种心理健康障碍,已成为全球公共卫生领域所面对的重要挑战之一。探究抑郁症的发病机制、准确评估抑郁症的症状变化,是制定有效临床诊疗策略的基础。借助功能磁共振成像、头皮脑电等非侵入脑成像技术,已有研究证实抑郁症的发生与大脑多个脑区的神经活动异常以及功能连通性改变密切相关。脑磁图技术不受组织导电率和颅骨厚度等影响,其空间分辨率和信噪比高,在深入揭示抑郁症的异常脑机制和神经特征方面具有独特优势和重要价值。本综述从抑郁症患者的脑磁图节律特征、非线性动力学特征以及连通性特征出发,回顾抑郁症相关的脑磁图特征研究进展,并探讨当前存在的问题和未来发展趋势,为抑郁症相关病理生理机制研究以及临床诊疗提供启示。Depression,a mental health disorder,has emerged as one of the significant challenges in the global public health domain.Investigating the pathogenesis of depression and accurately assessing the symptomatic changes are fundamental to formulating effective clinical diagnosis and treatment strategies.Utilizing non-invasive brain imaging technologies such as functional magnetic resonance imaging and scalp electroencephalography,existing studies have confirmed that the onset of depression is closely associated with abnormal neural activities and altered functional connectivity in multiple brain regions.Magnetoencephalography,unaffected by tissue conductivity and skull thickness,boasts high spatial resolution and signal-to-noise ratio,offering unique advantages and significant value in revealing the abnormal brain mechanisms and neural characteristics of depression.This review,starting from the rhythmic characteristics,nonlinear dynamic features,and connectivity characteristics of magnetoencephalography in depression patients,revisits the research progress on magnetoencephalography features related to depression,discusses current issues and future development trends,and provides insights for the study of pathophysiological mechanisms,as well as for clinical diagnosis and treatment of depression.

关 键 词：抑郁症 脑磁图 节律 非线性动力学 连通性 

分 类 号：TN911.7[电子电信—通信与信息系统] R749.4[电子电信—信息与通信工程]