彩超血流参数联合血清STK1水平检测对甲状腺结节性质的鉴别诊断价值  

Value of Color Doppler Ultrasound Blood Flow Parameters Combined with Serum STK1 Level in Differential Diagnosis of Thyroid Nodules

作　　者：邓淑敏 朱海侠 DENG Shumin;ZHU Haixia(Department of Health Management,Xinyang Central Hospital,Xinyang 464000,China)

机构地区：[1]信阳市中心医院健康管理科,河南信阳464000

出　　处：《河南医学研究》2025年第3期456-459,共4页Henan Medical Research

摘　　要：目的 分析彩超血流参数[阻力指数(RI)、收缩期峰值流速(PSV)、舒张期末流速(EDV)、血管血流指数(VFI)水平]联合血清胸苷激酶1(STK1)水平检测对甲状腺结节性质的鉴别诊断价值。方法 2021年6月至2023年6月收集信阳市中心医院100例甲状腺结节患者为研究对象,根据病理结果分为良性结节组(76例)、恶性结节组(24例),对比两组超声学特征分布情况、血流动力学参数、血清STK1水平及临床常见诊断指标癌胚抗原(CEA)、甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPOAb)水平,并分析其相关性及对恶性甲状腺结节的诊断价值。结果 良性结节患者血流动力学参数PSV、VFI、EDV、RI及血清STK1、CEA、TPO-Ab、TGAb水平均低于恶性结节患者、良性甲状腺结节患者血流动力学参数EDV均高于恶性甲状腺结节患者(P<0.05);血清STK1与CEA、TPO-Ab、TgAb均呈正相关(P<0.05);入院时彩超血流参数及血清STK1水平联合检测对诊断恶性甲状腺结节的曲线下面积(AUC)为0.778。结论 入院时彩超血流参数联合血清STK1水平联合检测可提高对疾病的灵敏度,二者联合检测对鉴别甲状腺结节良恶性具有重要临床应用价值。Objective To analyze the value of color Doppler ultrasound blood flow parameters[resistance index(RI),peak systolic velocity(PSV),end diastolic velocity(EDV),vascular flow index(VFI)levels]combined with serum thymidine kinase 1(STK1)level in the differential diagnosis of thyroid nodules.Methods From June 2021 to June 2023,100 patients with thyroid nodules in Xinyang Central Hospital were selected as the research objects,and they were divided into benign nodules group(76 cases)and malignant nodules group(24 cases)according to the pathological results.The distribution of ultrasonic characteristics,hemodynamic parameters and serum STK1 level were compared between the two groups,the levels of common clinical diagnostic indicators carcinoembryonic antigen(CEA),thyroglobulin antibody(TGAb)and thyroid peroxidase antibody(TPOAb)were compared,the correlation and diagnostic value for malignant thyroid nodules were analyzed.Results The hemodynamic parameters of PSV,VFI,EDV,RI and serum levels of STK1,CEA,TPO-Ab,TGAb in patients with benign nodules were lower than those in patients with malignant nodules,and the hemodynamic parameter of EDV in patients with benign thyroid nodules was higher than that in patients with malignant thyroid nodules(P<0.05).Serum STK1 was positively correlated with CEA,TPO-Ab and TGAb(P<0.05).The area under the curve(AUC)of color Doppler ultrasound blood flow parameters and serum STK1 level in the diagnosis of malignant thyroid nodules at admission was 0.778.Conclusion The combined detection of color Doppler ultrasound blood flow parameters and serum STK1 level at admission can improve the sensitivity of the disease,and the combined detection of the two has important clinical application value in differentiating benign and malignant thyroid nodules.

关 键 词：甲状腺结节 胸苷激酶1 彩超血流参数 

分 类 号：R445[医药卫生—影像医学与核医学]