不同频率血液透析滤过联合高通量血液透析对重症肝炎肝衰竭预后的影响  

Effect of Different Frequency Hemodialytic Filtration Combined with High Throughput Hemodialysis on Prognosis of Liver Failure in Severe Hepatitis

作　　者：盛伟 张小凯 边文亚 SHENG Wei;ZHANG Xiaokai;BIAN Wenya(Hemodialysis Room,Kaifeng Central Hospital,Kaifeng 475000,China)

机构地区：[1]开封市中心医院透析室,河南开封475000

出　　处：《河南医学研究》2025年第3期475-479,共5页Henan Medical Research

摘　　要：目的 探讨不同频率血液透析滤过联合高通量血液透析对重症肝炎肝衰竭预后的影响。方法 选取2020年9月至2022年9月在开封市中心医院就诊的68例重症肝炎肝衰竭患者,所有患者均进行血液透析滤过联合高通量血液透析治疗,依据血液透析不同频率分组,将频率为每月1次的34例患者纳入对照组,将频率为每周1次的34例患者纳入观察组。统计两组患者肝功能、血管相关分子物质清除情况、营养状况及近期不良事件发生率。结果 干预前,两组肝功能比较,差异无统计学意义(P>0.05);干预后,两组肝功能指标均较干预前下降,组间比较,观察组肝功能指标低于对照组(P<0.05)。干预前,两组血尿素氮、肌酐、血磷、血钾、血钙水平比较,差异无统计学意义(P>0.05);干预后,两组血尿素氮、肌酐、血磷、血钾、血钙水平均较干预前下降,组间比较,观察组血尿素氮、肌酐、血磷、血钾、血钙水平低于对照组(P<0.05)。干预前,两组营养状况比较,差异无统计学意义(P>0.05);干预后,两组营养状况指标均较干预前上升,组间比较,观察组营养状况指标高于对照组(P<0.05)。两组近期不良事件发生率比较,差异无统计学意义(P>0.05)。结论 每周1次血液透析滤过联合高通量血液透析可有效改善重症肝炎肝衰竭预后,改善患者营养状态及肝功能,有效清除血管相关分子物质,促进患者恢复。Objective To investigate the effect of different frequency hemodialyfiltration combined with high throughput hemodialysis on the prognosis of liver failure in severe hepatitis.Methods A total of 68 patients with severe hepatitis and liver failure treated in Kaifeng Central Hospital from September 2020 to September 2022 were selected,all of whom were treated with hemodialysis filtration combined with high throughput hemodialysis.According to different frequency of hemodialysis,34 patients with a frequency of once a month were included in the control group,and 34 patients with a frequency of once a week were included in the observation group.Liver function,clearance of vascular-related molecular substances,nutritional status and recent adverse events were analyzed in the two groups.Results Before intervention,there was no statistically significant difference in liver function between the two groups(P>0.05).After intervention,liver function indexes of the two groups were decreased compared with those before intervention.Compared between groups,liver function indexes of the observation group were lower than those of the control group(P<0.05).Before intervention,there was no statistical significance in the levels of blood urea nitrogen,creatinine,phosphorus,potassium and calcium between the two groups(P>0.05).After intervention,the levels of blood urea nitrogen,creatinine,phosphorus,potassium and calcium in the two groups were decreased compared with those before intervention.Compared between groups,the levels of blood urea nitrogen,creatinine,phosphorus,potassium and calcium in the observation group were higher than those in the control group(P<0.05).Before intervention,there was no significant difference in the nutritional status between the two groups(P>0.05).After intervention,the nutritional status indexes of the two groups were higher than that before intervention,and the nutritional status indexes of the observation group were lower than those of the control group(P<0.05).There was no significant difference in

关 键 词：重症肝炎 肝衰竭 血液透析 预后 

分 类 号：R512.6[医药卫生—内科学]