小剂量阿司匹林联合硫酸镁治疗早发型子痫前期的效果  

Effect of Low-dose Aspirin Combined with Magnesium Sulfate in the Treatment of Early-onset Preeclampsia

作　　者：刘皓 侯绍亮 贾锐 王圣杰 LIU Hao;HOU Shaoliang;JIA Rui;WANG Shengjie(Reproductive Genetics and Prenatal Diagnosis Center Laboratory,Hebi People’s Hospital,Hebi 458030,China;Hebi City Key Laboratory of Assisted Reproductive Technology,Hebi People’s Hospital,Hebi 458030,China;Reproductive Genetics and Prenatal Diagnosis Center,Hebi People’s Hospital,Hebi 458030,China)

机构地区：[1]鹤壁市人民医院生殖遗传与产前诊断中心实验室,河南鹤壁458030 [2]鹤壁市人民医院鹤壁市辅助生殖技术重点实验室,河南鹤壁458030 [3]鹤壁市人民医院生殖遗传与产前诊断中心,河南鹤壁458030

出　　处：《河南医学研究》2025年第3期511-515,共5页Henan Medical Research

摘　　要：目的 研究小剂量阿司匹林联合硫酸镁治疗早发型子痫前期的效果及对胎盘生长因子(PIGF)、可溶性fms样酪氨酸激酶受体1(sFlt-1)、sFlt-1/PIGF水平的影响。方法 招募鹤壁市人民医院2020年9月至2022年5月收治的156例早发型子痫前期患者为研究对象,按随机数表法分为对照组和研究组,各78例。对照组接受硫酸镁治疗,研究组接受小剂量阿司匹林联合硫酸镁治疗,两组均治疗7 d。比较两组患者治疗前后的血压指标[24 h平均舒张压(DBP)、收缩压(SBP)]、胎盘指标(PIGF、sFlt-1、sFlt-1/PIGF)、脐动脉血流动力指标[脐动脉搏动指数(UAPI)、脐动脉阻力指数(UARI)、收缩末期峰值/舒张末期峰值(S/D)]差异,记录治疗期间药物不良反应,随访患者至分娩记录母婴结局[妊娠方式、不良妊娠情况、新生儿评分(Apgar评分)]。结果 治疗7 d,两组患者PIGF上升,24 h平均DBP、SBP和sFlt-1、sFlt-1/PIGF、UAPI、UARI、S/D均下降,且研究组PIGF高于对照组,24 h平均DBP、SBP和sFlt-1、sFlt-1/PIGF、UAPI、UARI、S/D低于对照组,差异有统计学意义(P<0.05);治疗期间,两组总药物不良反应发生率差异无统计学意义(P>0.05);随访至患者分娩,研究组子痫、早产发生率低于对照组,Apgar评分高于对照组(P<0.05),两组胎儿窘迫、胎儿窒息、产后出血、胎盘早剥发生率差异无统计学意义(P>0.05)。结论 小剂量阿司匹林联合硫酸镁可有效调节早发型子痫前期患者血压水平,提升PIGF,降低sFlt-1。Objective To study the effect of low-dose aspirin combined with magnesium sulfate on early-onset preeclampsia and its influence on the levels of placental growth factor(PIGF),soluble fms-like tyrosine kinase receptor 1(sFlt-1)and sFlt-1/PIGF.Methods A total of 156 patients with early-onset preeclampsia admitted to Hebi People’s Hospital from September 2020 to May 2022 were recruited as research subjects,and were divided into control group and study group according to the random number table method,with 78 cases in each group.The control group received magnesium sulfate treatment,and the study group was given low-dose aspirin combined with magnesium sulfate,and both groups were treated for 7 days.The differences in blood pressure indicators[24 hours mean diastolic blood pressure(DBP),systolic blood pressure(SBP)],placental indicators(PIGF,sFlt-1,sFlt-1/PIGF),umbilical artery hemodynamic indicators[umbilical artery pulsatility index(UAPI),umbilical artery resistance index(UARI),end-systolic peak/end-diastolic peak(S/D)]were compared between the two groups of patients before and after treatment.Adverse drug reactions were recorded during treatment,and the maternal-infant outcomes[pregnancy mode,adverse pregnancy,neonatal score(Apgar score)]were recorded during follow-up to delivery.Results After 7 days of treatment,the PIGF was increased in both groups while the 24 hours mean DBP,SBP,sFlt-1,sFlt-1/PIGF,UAPI,UARI,and S/D were decreased,and the PIGF in study group was higher than that in control group while the 24 hours mean DBP,SBP,sFlt-1,sFlt-1/PIGF,UAPI,UARI,and S/D were lower than those in control group(P<0.05).There was no statistically significant difference in the total incidence rate of adverse drug reactions between the two groups during treatment(P>0.05).After follow-up to delivery,the incidence rates of eclampsia and preterm birth were lower in study group than those in control group while the Apgar score was higher than that in control group(P<0.05).There were no statistical differences in the incidence

关 键 词：早发型子痫前期 小剂量阿司匹林 硫酸镁 脐动脉血流动力 可溶性fms样酪氨酸激酶受体1 胎盘生长因子 

分 类 号：R714.244[医药卫生—妇产科学]