树突状细胞在重症肌无力免疫机制中的研究进展  

Research Progress on Dendritic Cells in the Immune Mechanism of Myasthenia Gravis

作　　者：贺伊涵 文颖娟[1] 张帅[1] 王兴兵 张锦虹 陈亚莉 胥冰[1] HE Yihan;WEN Yingjuan;ZHANG Shuai;WANG Xingbing;ZHANG Jinhong;CHEN Yali;XU Bing(Shaanxi University of Chinese Medicine,Xianyang 712046,China;The First Clinical Medical College,Shaanxi University of Chinese Medicine,Xianyang 712046)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学第一临床医学院,陕西咸阳712046

出　　处：《现代中医药》2025年第2期9-15,共7页Modern Chinese Medicine

基　　金：国家自然科学基金项目(81202642);陕西省重点研发计划(S2023-YF-YBSF-0969)。

摘　　要：树突状细胞(Dendritic Cells,DC)作为抗原递呈细胞中的佼佼者,不仅具有强大的抗原递呈能力,还在免疫耐受中扮演着关键角色。如何利用DC的免疫耐受特性来治疗自身免疫性疾病,已成为免疫学研究的热点。重症肌无力作为一种T细胞依赖、抗体介导、器官特异的自身免疫病,其治疗也迎来了新的突破点——利用DC的免疫耐受特性。近年来,围绕DC的耐受特性、诱导耐受机制及其利用细胞因子诱导获得耐受性DC、DC负载乙酰胆碱受体或免疫优势肽段、基因修饰DC、特异性抑制核因子κB依赖的基因表达等治疗重症肌无力应用研究不断增多,为这一疾病的治疗提供了新的思路和方向。Dendritic cells(DC),as outstanding antigen-presenting cells,not only possess powerful antigen-presenting capabilities but also play a crucial role in immune tolerance.How to harness the immune tolerance characteristics of DC to treat autoimmune diseases has become a hot topic in immunological research.Myasthenia gravis,as a T cell-dependent,antibody-mediated,organ-specific autoimmune disease,has seen a new breakthrough in treatment—utilizing the immune tolerance properties of DC.In recent years,research on the tolerance characteristics of DC,the mechanisms of inducing tolerance,and the application of cytokine-induced tolerogenic DC,DC loaded with acetylcholine receptors or immunodominant peptides,genetically modified DC,and specific inhibition of nuclear factor-κB-dependent gene expression for the treatment of myasthenia gravis has been increasing.These studies provide new insights and directions for the treatment of this disease.

关 键 词：树突状细胞 重症肌无力 免疫耐受 调节性T细胞 耐受性树突状细胞 

分 类 号：R285.5[医药卫生—中药学]