白细胞介素-36在炎症性肠病中的作用研究新进展  

New Advances in the Role of Interleukin-36 in Inflammatory Bowel Disease

作　　者：朱俊丰 韩忠阳 唐琼 ZHU Jun-feng;HAN Zhong-yang;TANG Qiong(Affiliated Hospital of Guilin Medical University,Guilin 541001)

机构地区：[1]桂林医学院附属医院,广西桂林541001

出　　处：《微生物学杂志》2025年第1期117-123,共7页Journal of Microbiology

基　　金：国家自然科学基金项目(82360113);广西自然科学基金面上项目(2021GXNSFAA325001,2024GXNSFAA010059);广西高等学校千名中青年骨干教师培育计划项目(桂教教师〔2020〕58号);广西研究生教育创新计划项目(YCSW2022373)。

摘　　要：白细胞介素36(Interleukin-36,IL-36)属于IL-1超家族的一组细胞因子。越来越多的证据表明,IL-36在许多炎症性疾病的发病机制中起着作用。而在肠道中,IL-36具有相当复杂的功能。IL-36受体配体在动物结肠炎模型和炎症性肠病患者中均过度表达,并且可能根据所处炎症的不同阶段发挥病理和保护作用。IL-36细胞因子包括三种受体激动剂IL-36α、IL-36β、IL-36γ和两种受体拮抗剂IL-36Ra和IL-38。所有IL-36受体激动剂都能结合IL-36R复合物,并在炎症状态下发挥多种作用。本文首先简要回顾炎症性肠病的发病机制及IL-36细胞因子在免疫调控中的作用,随后重点关注IL-36在肠道炎症疾病中的免疫学效应。此外,讨论了通过阻断IL-36R信号通路以治疗慢性肠道炎症的相关研究,以及IL-36相关研究中的一些未被探索的问题。Interleukin-36(IL-36)is a group of cytokines belonging to the IL-1 superfamily.Increasing evidence suggests that IL-36 plays a role in the pathogenesis of various inflammatory diseases.In the gastrointestinal tract,IL-36 exerts a complicated role.IL-36 receptor ligands are overexpressed in both animal models of colitis and in patients with inflammatory bowel disease(IBD),potentially playing both pathological and protective roles depending on the stage of inflammation.IL-36 cytokines include three receptor agonists:IL-36α,IL-36β,and IL-36γ,as well as two receptor antagonists:IL-36Ra and IL-38.All IL-36 receptor agonists bind to the IL-36R complex and exhibit diverse functions during inflammatory states.This article first provides a brief overview of the pathogenesis of inflammatory bowel disease and the role of IL-36 cytokines in immune regulation,followed by a focus on the immunological effects of IL-36 in intestinal inflammatory diseases.Additionally,we discuss research on the potential therapeutic approach of blocking the IL-36R signaling pathway for chronic intestinal inflammation,along with some unresolved issues in IL-36-related studies.

关 键 词：炎症性肠病 白介素-36 免疫调节 研究进展 发病机制 

分 类 号：Q939.93[生物学—微生物学]