大颗粒明胶海绵行子宫动脉栓塞术联合米非司酮治疗剖宫产瘢痕妊娠的疗效观察  

Observation on the curative effect of uterine artery embolization with large particle gelatin sponge combined with mifepristone in the treatment of cesarean scar pregnancy

作　　者：张磊[1] 吴常生[1] 包巴特尔 穆永旭[1] 闫瑞强[1] ZHANG Lei;WU Changsheng;BAO Batel(Department of Interventional Vascular Surgery,The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China)

机构地区：[1]内蒙古科技大学包头医学院第一附属医院介入血管外科,内蒙古包头014010

出　　处：《医师在线》2025年第2期63-66,共4页Journal of Doctors Online

基　　金：内蒙古自治区高等学校科学研究项目(NJZZ21046);包头医学院青年科技人才发展计划(BYJJ-QNGG 2022026,BYJJ-QNGG 2022032)。

摘　　要：目的探讨大颗粒明胶海绵子宫动脉栓塞术联合米非司酮治疗剖宫产瘢痕妊娠(CSP)的疗效。方法选择2018年1月~2022年12月在我院行介入诊疗的80例CSP患者为研究对象,其中试验组40例,对照组40例。两组患者均行子宫动脉化疗栓塞术联合清宫术治疗,试验组在上述治疗基础上给予口服米非司酮片治疗,每天2次,每次50 mg,连续服药5 d。比较两组患者的临床疗效、恢复情况、卵巢功能、治疗满意度。结果试验组治疗总有效率为100.00%,对照组的治疗总有效率为97.50%,两组比较差异无统计学意义(χ^(2)=1.013,P=0.314)。两组住院时间、月经复潮时间、β-人绒毛膜促性腺激素(β-HCG)恢复正常时间比较,试验组明显优于对照组(P<0.05)。两组术前、术后黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)等卵巢功能指标组内、组间比较,差异均无统计学意义(P>0.05)。试验组治疗总满意度97.50%高于对照组的85.00%(P<0.05)。结论大颗粒明胶海绵行子宫动脉栓塞术联合米非司酮治疗CSP患者的治疗效果较好,可减少对卵巢功能的损伤,术后恢复快,且提高患者的治疗满意度。Objective To investigate the efficacy of large particle gelatin sponge uterine artery embolization combined with mifepristone in the treatment of cesarean scar pregnancy(CSP).Methods A total of 80 patients with CSP who underwent interventional diagnosis and treatment in our hospital from January 2018 to December 2022 were selected as the research objects,including 40 cases in the experimental group and 40 cases in the control group.Both groups were treated with uterine artery chemoembolization combined with uterine curettage.The experimental group was treated with oral mifepristone tablets on the basis of the above treatment,twice a day,50 mg each time,for 5 days.The clinical efficacy,recovery,ovarian function and treatment satisfaction of the two groups were compared.Results The total effective rate of treatment in the experimental group was 100.00%,and the total effective rate of treatment in the control group was 97.50%.There was no significant difference between the two groups(χ^(2)=1.013,P=0.314).The hospitalization time,menstrual recovery time andβ-human chorionic gonadotropin(β-HCG)recovery time of the two groups were compared,and the experimental group was significantly better than the control group(P<0.05).There was no significant difference in ovarian function indexes such as luteinizing hormone(LH),follicle stimulating hormone(FSH)and estradiol(E2)between the two groups before and after operation(P>0.05).The total treatment satisfaction of the experimental group was 97.50%higher than that of the control group(85.00%)(P<0.05).Conclusion Uterine artery embolization with large particle gelatin sponge combined with mifepristone is effective in the treatment of CSP patients,which can reduce the damage to ovarian function,recover quickly after operation,and improve the treatment satisfaction of patients.

关 键 词：大颗粒栓塞剂 子宫动脉栓塞术 米非司酮 剖宫产瘢痕妊娠 

分 类 号：R714.22[医药卫生—妇产科学]