瑞马唑仑用于肥胖患者腹腔镜胃袖状切除术全身麻醉诱导期对患者体征波动及苏醒质量的影响  

Effect of Remazolam on the Fluctuation of Signs and the Quality of Recovery in Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy During Induction Period of General Anesthesia

作　　者：刘洋 曾景阳[1] LIU Yang;ZENG Jingyang(Department of Anesthesiology,Quanzhou First Hospital,Quanzhou,Fujian 362000,China)

机构地区：[1]泉州市第一医院麻醉科,福建泉州362000

出　　处：《中国医药指南》2025年第6期42-45,共4页Guide of China Medicine

摘　　要：目的研究瑞马唑仑在肥胖患者腹腔镜胃袖状切除术全身麻醉诱导期对患者体征波动及苏醒质量的影响。方法选择泉州市第一医院2020年3月至2023年3月收治的因过度肥胖拟行腹腔镜胃袖状切除术患者90例为研究对象,按照随机数字表法,将其分为瑞马唑仑组和常规麻醉对照组两组,每组均有45例受试者。常规麻醉对照组患者在全身麻醉诱导期接受咪达唑仑麻醉,瑞马唑仑组在全身麻醉诱导期使用瑞马唑仑麻醉。对比两组患者的苏醒质量、血流动力学、认知功能及不良反应情况。结果瑞马唑仑组苏醒时长、气管导管移除耗时、恢复室停留时长均短于常规麻醉对照组(P<0.05)。瑞马唑仑组T_(0)、T_(1)、T_(2)、T_(3)四个节点的平均动脉压(MAP)、心率(HP)两项观察指标均低于常规麻醉对照组(P<0.05)。麻醉清醒后瑞马唑仑组认知功能评分较常规麻醉对照组高(P<0.05)。瑞马唑仑组不良反应发生率低于2.22%常规麻醉对照组17.76%(P<0.05)。结论瑞马唑仑应用于肥胖患者腹腔镜胃袖状切除术全身麻醉诱导期的效果较好,对患者生命体征的波动影响较小,患者苏醒速度相对较快,其在麻醉镇静方面具有较好的应用前景。Objective To study the effects of remazolam on the fluctuation of physical signs and the quality of recovery in obese patients during the induction period of laparoscopic gastric sleeve resection under general anesthesia.Methods A total of 90 patients who were to laparoscopic sleeve gastrectomy due to excessive obesity and were admitted to the Quanzhou First Hospital from March 2020 to March 2023 were selected as the study subjects.According to the random number table method,they were divided into two groups:the remifentanil group and the conventional anesthesia control group,with 45 subjects in each group.The control group received midazolam anesthesia during the induction period of general anesthesia,while the remifentanil group received remifentanil anesthesia during the induction period of general anesthesia.Compare the quality of recovery,hemodynamics,cognitive function,and adverse reactions between two groups of patients.Results The recovery time,tracheal tube removal time,and recovery room stay time in the remifentanil group were all shorter than those in the conventional anesthesia control group(P<0.05).The mean arterial pressure(MAP)and heart rate(HP)at T_(0),T_(1),T_(2) and T_(3) nodes in remazolam group were lower than those in conventional anesthesia control group(P<0.05).The cognitive function score of remazolam group after anesthesia was higher than that of conventional anesthesia control group(P<0.05).The incidence of adverse reactions in the remifentanil group was lower(2.22%)than in the conventional anesthesia control group,which was 17.76%(P<0.05).Conclusions Remazolam has a good effect in the induction period of laparoscopic gastric sleeve resection in obese patients with general anesthesia,and has little influence on the fluctuation of patients’vital signs,and the recovery rate of patients is relatively fast.Remazolam has a good application prospect in anesthesia and sedation.

关 键 词：肥胖患者 腹腔镜 胃袖状切除术 全身麻醉诱导期 苏醒质量 

分 类 号：R614[医药卫生—麻醉学] R589.2[医药卫生—外科学]