血清TGAb、TpoAb、TRAb联合检测在甲状腺疾病诊断中的应用价值  

The Application Value of Combined Detection of Serum TGAb,TpoAb,and TRAb in the Diagnosis of Thyroid Diseases

作　　者：张明方 周慧敏 李正伟 ZHANG Mingfang;ZHOU Huimin;LI Zhengwei(Department of Laboratory,Jiangsu Sihong Zhongxin Hospital,Sihong,Jiangsu 223900,China)

机构地区：[1]江苏省泗洪中信医院检验科,江苏泗洪223900

出　　处：《中国医药指南》2025年第6期129-131,共3页Guide of China Medicine

摘　　要：目的分析血清甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TpoAb)、促甲状腺激素受体抗体(TRAb)联合诊断甲状腺疾病的价值。方法选取江苏省泗洪中信医院在2022年1月至2023年11月接收的158例甲状腺疾病患者及80名健康体检人员作为研究对象,按照是否为自身免疫性甲状腺疾病将患者分为观察A组(自身免疫性)、观察B组(非自身免疫性),分别为80例、78例。同时以80名健康体检人员作为对照组。检测所有研究对象的血清TGAb、TpoAb、TRAb水平并作对比,分析其在不同研究对象中的表达情况。此外,比较TGAb、TpoAb、TRAb三项指标单独检测及联合检测在甲状腺疾病诊断中的应用价值。结果观察A组三项血清指标水平均高于观察B组、对照组,且观察B组三项指标水平高于对照组(F=596.478、233.919、885.336;均P<0.05);TGAb、TpoAb、TRAb三项指标联合检测的ROC曲线面积(0.781)高于各指标单一检测的ROC曲线面积。结论在甲状腺疾病患者中,自身免疫性疾病患者的TGAb、TpoAb、TRAb水平表达情况最高,且TGAb、TpoAb、TRAb三项指标在甲状腺疾病诊断中的效能较高,可作为判断患者是否发生甲状腺疾病的参考依据。Objective To explore the application value of combined detection of serum thyroglobulin antibody(TGAb),thyroid peroxidase antibody(TpoAb),and thyroid stimulating hormone receptor antibody(TRAb)in the diagnosis of thyroid diseases.Methods A total of 158 patients with thyroid diseases and 80 healthy individuals who underwent physical examinations at Zhongxin Hospital in Sihong,Jiangsu Province from January 2022 to November 2023 were selected as the research subjects.Patients were divided into observation group A(autoimmune)and observation group B(non autoimmune)based on whether they had autoimmune thyroid diseases,with 80 and 78 cases respectively.A total of 80 cases of healthy personnel were also selected and included in the study and used as control subjects.Detect and compare the serum levels of TGAb,TpoAb,and TRAb in all study subjects,and analyze their expression in different study subjects.In addition,draw receiver operating characteristic curve(ROC)to compare the application value of individual and combined detection of TGAb,TpoAb,and TRAb in the diagnosis of thyroid diseases.Results The levels of TGAb,TpoAb,and TRAb in observation group A were higher than those in observation group B and the control group,moreover,the level of three indicators in observation group B was higher than that of the other group(F=596.478;233.919;885.336;all P<0.05).The ROC curve area(0.781)of the combined detection of TGAb,TpoAb,and TRAb was higher than that of the single detection of each indicator.Conclusions Among patients with thyroid diseases,patients with autoimmune diseases have the highest expression levels of TGAb,TpoAb,and TRAb,and the three indicators of TGAb,TpoAb,and TRAb have higher efficacy in the diagnosis of thyroid diseases,which can serve as a reference basis for determining whether patients have thyroid diseases.

关 键 词：甲状腺疾病 自身免疫性 非自身免疫性 血清甲状腺球蛋白抗体 甲状腺过氧化物酶抗体 促甲状腺激素受体抗体 诊断价值 

分 类 号：R581[医药卫生—内分泌]