基于多组学的脓毒症分型及精准治疗研究进展  

Research progress on multi-omics-based sepsis subtyping and precision medicine

作　　者：谢牧天 惠亮亮[2] Xie Mutian;Hui Liangliang(Nanjing Medical University Graduate School,Nanjing 211166,China)

机构地区：[1]南京医科大学研究生院,江苏南京211166 [2]南京医科大学附属淮安第一医院重症医学科,江苏淮安223001

出　　处：《中国急救医学》2025年第3期257-262,共6页Chinese Journal of Critical Care Medicine

基　　金：南京医科大学附属淮安第一医院高层次人才科研项目(YGRS202010);徐州医科大学附属医院发展基金项目(XYFM202231)。

摘　　要：脓毒症是一种严重的危及患者生命健康的疾病,其病死率高,临床表现具有高度异质性,因此救治仍存在诸多挑战,尤其在精准治疗方面。随着基因组学、转录组学、蛋白质组学和代谢组学的发展,对脓毒症的认识也不断加深。本研究通过归纳基于多组学的脓毒症分型研究进展,以期能够为今后脓毒症分型研究提供新视角,并为脓毒症的精准治疗提供新思路。Sepsis is a severe disease that poses a significant threat to patients′life and health safety,with a high overall mortality rate.Its clinical manifestations are highly heterogeneous,so treatment still faces many challenges,especially in the field of precision medicine.With the development of multi-omics,such as genomics,transcriptomics,proteomics and metabolomics,our understanding of sepsis has been continuously deepening.This article summarizes the research progress of sepsis typing based on multi-omics,hoping to provide a new perspective for subsequent sepsis typing research,and further to assist in the development of precision medicine.

关 键 词：脓毒症 分型 精准治疗 基因组学 转录组学 蛋白质组学 代谢组学 

分 类 号：R459.7[医药卫生—急诊医学]