病毒性肝炎肝硬化患者血清干扰素α2a、5’-核苷酸酶、天冬氨酸转氨酶/丙氨酸转氨酶水平变化与肝储备功能关系及其对合并腹水的预测价值  

Relationship between serum levels of interferon IFN-α2a、5’-NT、AST/ALT and liver reserve function in patients with viral hepatitis and cirrhosis and their predictive value for ascites

作　　者：王嫄嫄 陈洪波 WANG Yuanyuan;CHEN Hongbo(Xingtai Central Hospital,Xingtai 054000,China)

机构地区：[1]邢台市中心医院,河北邢台054000

出　　处：《陕西医学杂志》2025年第3期369-373,共5页Shaanxi Medical Journal

基　　金：河北省医学科学研究课题(202015631)。

摘　　要：目的:探究病毒性肝炎肝硬化患者血清干扰素α2a(IFN-α2a)、5’-核苷酸酶(5’-NT)、天冬氨酸转氨酶/丙氨酸转氨酶(AST/ALT)水平变化与肝储备功能的关系及其对合并腹水的预测价值。方法:纳入病毒性肝炎肝硬化患者85例为研究组,纳入同期体检健康者85例为对照组。比较两组肝功能指标[AST、ALT、白蛋白(ALB)、总胆红素(STB)]、肝储备功能指标[吲哚菁绿15 min滞留率(ICGR 15)、肝有效血流量(EHBF)、肝功能CTP评分]以及IFN-α2a、5’-NT、AST/ALT水平。分析IFN-α2a、5’-NT、AST/ALT水平与肝储备功能指标的相关性。根据患者是否合并腹水将研究组患者分为无腹水组和腹水组,比较两组上述指标。分析IFN-α2a、5’-NT、AST/ALT对病毒性肝炎肝硬化患者合并腹水的预测价值。结果:与对照组比较,研究组AST、ALT、STB、ICGR15、IFN-α2a、5’-NT、AST/ALT水平和CTP评分升高,ALB、EHBF水平降低(均P<0.05)。IFN-α2a、5’-NT、AST/ALT水平与ICGR15、CTP评分呈正相关,与EHBF呈负相关(均P<0.05)。85例患者中,未合并腹水54例(无腹水组),合并腹水31例(腹水组)。与无腹水组比较,腹水组ICGR 15、IFN-α2a、5’-NT、AST/ALT水平和CTP评分升高,ALB、EHBF水平降低(均P<0.05)。IFN-α2a、5’-NT、AST/ALT对病毒性肝炎肝硬化合并腹水有较高的预测价值,三项联合检测的预测价值更高(均P<0.05)。结论:病毒性肝炎肝硬化患者血清IFN-α2a、5’-NT、AST/ALT水平升高,与肝储备功能具有相关性,三项联合检测对合并腹水亦有良好的预测价值。Objective:To investigate the relationship between serum levels of interferonα2a(IFN-α2a),5’-nucleotidase(5’-NT),aspartate aminotransferase/alanine aminotransferase(AST/ALT)and liver reserve function in patients with viral hepatitis and cirrhosis and their predictive value for ascites.Methods:85 patients with viral hepatitis and cirrhosis were included in the study group,and 85 healthy subjects were included as control group.Liver function indexes(AST,ALT,ALB,STB),liver reserve function indexes(ICGR 15,EHBF,liver function CTP score)and IFN-α2a,5’-NT,AST/ALT levels were compared between the two groups.The correlations between IFN-α2a,5’-NT,AST/ALT levels and liver reserve function were analyzed.According to whether patients with ascites or not,the study group was divided into non-ascites group and ascites group,and the above indexes were compared between the two groups.The predictive value of IFN-α2a,5’-NT,AST/ALT for ascites in patients with viral hepatitis and cirrhosis was analyzed.Results:Compared with the control group,AST,ALT,STB,ICGR 15,IFN-α2a,5’-NT,AST/ALT levels and CTP score were increased in the study group,while ALB and EHBF levels were decreased(all P<0.05).IFN-α2a,5’-NT,AST/ALT levels were positively correlated with ICGR15 and CTP scores,and were negatively correlated with EHBF(all P<0.05).Among the 85 patients,there were 54 cases without ascites(non-ascites group)and 31 cases with ascites(ascites group).Compared with non-ascites group,ICGR15,IFN-α2a,5’-NT,AST/ALT levels and CTP score were increased in ascites group,while ALB and EHBF levels were decreased(all P<0.05).IFN-α2a,5’-NT,AST/ALT had high predictive value for viral hepatitis and cirrhosis complicated with ascites,and the three combined tests had higher predictive value(all P<0.05).Conclusion:The levels of serum IFN-α2a,5’-NT and AST/ALT in patients with viral hepatitis and cirrhosis are increased,which are correlated with liver reserve function,and the combined detection of three also has good predictive value

关 键 词：病毒性肝炎肝硬化 干扰素Α2A 5’-核苷酸酶 天冬氨酸转氨酶/丙氨酸转氨酶 肝储备功能 腹水 预测价值 

分 类 号：R512.6[医药卫生—内科学]