血清泛素特异性蛋白酶25、基质金属蛋白酶-8、壳三糖苷酶检测对重症急性胰腺炎患者预后的预测价值  

Predictive value of serum USP25,MMP-8,CHIT1 in prognosis of SAP patients

作　　者：李宁[1] 张芸海 冉涛 彭建华 曾惜 LI Ning;ZHANG Yunhai;RAN Tao;PENG Jianhua;ZENG Xi(Department of Critical Care Medicine,Qianjiang Hospital Affiliated to Chongqing University,Chongqing 409000,China)

机构地区：[1]重庆大学附属黔江医院重症医学科,重庆409000

出　　处：《陕西医学杂志》2025年第3期384-388,393,共6页Shaanxi Medical Journal

基　　金：重庆市自然科学基金资助面上项目(CSTC2019JCYJ-MXMX05708)。

摘　　要：目的:探讨血清泛素特异性蛋白酶25(USP25)、基质金属蛋白酶-8(MMP-8)、壳三糖苷酶(CHIT1)检测对重症急性胰腺炎(SAP)患者预后的预测价值。方法:纳入SAP患者150例,检测血清USP25、MMP-8、CHIT1水平,收集Ranson评分、急性生理学和慢性健康评估(APACHE)Ⅱ和序贯器官衰竭评估(SOFA)评分等资料,统计院内存活情况并将患者分为存活组和病死组。Pearson法分析USP25、MMP-8、CHIT1与Ranson评分、APACHEⅡ评分、SOFA评分的相关性。Logistic回归分析预后的影响因素。受试者工作特征(ROC)曲线评价血清三者对预后的预测价值。结果:150例患者中,病死42例,存活108例。病死组血清USP25、MMP-8、CHIT1水平高于存活组(均P<0.05)。SAP患者血清USP25、MMP-8、CHIT1水平与Ranson评分、APACHEⅡ评分、SOFA评分呈正相关(均P<0.05)。高Ranson评分、高水平USP25、高水平MMP-8和高水平CHIT1是SAP患者预后的危险因素(均P<0.05)。USP25、MMP-8、CHIT1联合预测SAP患者预后的曲线下面积(AUC)高于单项预测(均P<0.05)。结论:SAP患者血清USP25、MMP-8、CHIT1水平升高,联合检测对患者预后有良好的预测价值。Objective:To investigate the predictive value of serum ubiquitin-specific proteinase 25(USP25),matrix metalloproteinase-8(MMP-8),chitotriosidase(CHIT1)in the prognosis of patients with severe pancreatitis(SAP).Methods:A total of 150 patients with SAP were included.Serum USP25,MMP-8 and CHIT1 levels were detected.Clinical data such as Ranson,APACHEⅡand SOFA scores were collected.The hospital survival was analyzed and the patients were divided into survival group and death group.The correlations between USP25,MMP-8,CHIT1 and Ranson score,APACHEⅡscore and SOFA score were analyzed by Pearson method.Logistic regression was used to analyze the factors affecting prognosis.ROC curve was used to evaluate the predictive value of serum three markers for prognosis.Results:Of the 150 patients,42 died and 108 survived.The levels of USP25,MMP-8 and CHIT1 in death group were higher than those in survival group(all P<0.05).Serum USP25,MMP-8 and CHIT1 levels in SAP patients were positively correlated with Ranson score,APACHEⅡscore and SOFA score(all P<0.05).High Ranson score,high level of USP25,high level of MMP-8 and high level of CHIT1 were risk factors for prognosis in SAP patients(all P<0.05).The AUC of USP25,MMP-8 and CHIT1 combined predicted the prognosis of SAP patients was higher than that of single prediction(all P<0.05).Conclusion:Serum USP25,MMP-8 and CHIT1 levels were elevated in SAP patients,and combined detection had good prognostic value in SAP patients.

关 键 词：重症急性胰腺炎 泛素特异性蛋白酶25 基质金属蛋白酶-8 壳三糖苷酶 预后 预测价值 

分 类 号：R657.51[医药卫生—外科学]