乳腺导管原位癌超声表现与病理特征、免疫组化的相关性  

Correlation between ultrasound characteristics with pathological features and immunohistochemistry of ductal carcinoma in situ of breast

作　　者：王婉露 孙医学 李阳 叶伟丽 Wang Wanlu;Sun Yixue;Li Yang;Ye Weili(The First Affiliated Hospital of Bengbu Medical University,Bengbu,Anhui 233000,China)

机构地区：[1]蚌埠医科大学第一附属医学,安徽蚌埠233000

出　　处：《齐齐哈尔医学院学报》2025年第3期263-266,共4页Journal of Qiqihar Medical University

摘　　要：目的 探讨乳腺导管原位癌(Ductal carcinoma in situ, DCIS)的超声图像特征,并分析超声声像图与病理及免疫组化的相关性。方法 选择2022年9月—2024年6月在本院经手术确诊65例乳腺导管原位癌患者作为研究对象,所有患者术前均进行超声检查并进行BI-RADS分级,根据超声声像图分型,分为肿块型、非肿块型,病理特征包括低、中、高级别导管原位癌,并收集患者雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2 (HER2)状态。比较超声特征与病理表现及生物学标志物。结果 65例病变中,肿块34例(52.3%),非肿块31例(47.7%),最常见的肿块型形态为不规则21例(32.3%)、边界不清29例(44.7%)、低回声24例(36.9%)。24例(36.9%)伴有微钙化。肿块外钙化比肿块内钙化更常见。超声微钙化和导管改变常见于非肿块型病变。超声非肿块病变与高级别DCIS相关(P<0.05)。微钙化与高级别DCIS (P<0.001)、HER2阳性(P<0.05)明显相关。结论 联合分析超声表现与病理特征及免疫组化对DCIS的预后具有一定价值。Objective To explore the ultrasound image characteristics of ductal carcinoma in situ(DCIS)and analyze the correlation between ultrasound images,pathology,and immunohistochemistry.Methods A total of 65 patients with breast ductal carcinoma in situ(DCIS)diagnosed at our hospital from September 2022 to June 2024 were selected as subjects.Preoperative ultrasound examinations were conducted,and patients were classified into mass and non-mass types based on ultrasound imaging and BI-RADS grading.Pathological features included low,medium,and high-grade DCIS.The status of human epidermal growth factor receptor 2(HER2),estrogen receptor(ER),and progesterone receptor(PR)was also collected.Ultrasound features were compared with pathological manifestations and biological markers.Results Among the 65 lesion cases,34 cases(52.3%)were masses and 31 cases(47.7%)were non-masses.The most common mass types were irregular in 21 cases(32.3%),with unclear boundaries in 29 cases(44.7%),and low echogenicity in 24 cases(36.9%).Microcalcifications were present in 24 cases(36.9%).Calcification outside the mass was more common than inside the mass.Ultrasound microcalcifications and ductal changes were common in non-mass lesions.Non-mass lesions were associated with high-grade DCIS(P<0.05).Microcalcification was significantly correlated with high-grade DCIS(P<0.001)and HER2 positivity(P<0.05).Conclusions The combined analysis of ultrasound images,pathological characteristics,and immunohistochemistry has certain value for the prognosis of DCIS.

关 键 词：乳腺导管原位癌 病理特征 人表皮生长因子受体2 

分 类 号：R73[医药卫生—肿瘤]