维生素D与胰岛素抵抗相关性的研究进展  

Research progress on the correlation between vitamin D and insulin resistance

作　　者：秦楠 蒋升[1] 蒋依琪 朱霞 Qin Nan;Jiang Sheng;Jiang Yiqi;Zhu Xia(Department of Endocrinology,the First Affiliated Hospital of Xinjiang Medical University,State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院内分泌科、省部共建中亚高发病成因与防治国家重点实验室,乌鲁木齐830054

出　　处：《中国医药》2025年第3期463-466,共4页China Medicine

基　　金：新疆维吾尔自治区科技创新团队(天山创新团队)项目(2022TSYCTD0014);新疆医科大学大学生创新训练计划项目(202310760018)。

摘　　要：维生素D是一种类固醇衍生物,在多种代谢过程中起着重要作用,维生素D缺乏症在人群中普遍存在,最新研究证据显示维生素D不足可能与胰岛素抵抗(IR)相关疾病的发病机制有关,补充维生素D除了对骨骼健康有益处,在改善IR中的作用亦不容忽视。本综述总结了已报道的维生素D对IR的作用,补充了维生素D通过各种途径改善IR的机制,认为将维生素D维持在充足水平对改善IR有着一定的作用,对2型糖尿病患者的血糖控制有一定的帮助,在未来2型糖尿病治疗中,补充维生素D联合目前已知降糖方案同时治疗不失为未来的一种综合性个体化治疗。Vitamin D is a steroid derivative that plays an important role in a variety of metabolic processes.Vitamin D deficiency is common in the population.The latest research evidence shows that vitamin D deficiency may be related to the pathogenesis of insulin resistance(IR)-related diseases.In addition to the benefits of vitamin D supplementation for bone health,its role in improving IR should not be ignored.This review summarizes the reported effects of vitamin D on IR,supplements the mechanisms of vitamin D improving IR through various pathways,and concludes that maintaining vitamin D at an adequate level has a certain effect on improving IR and is helpful for blood glucose control in patients with type 2 diabetes.In the future treatment of type 2 diabetes,Vitamin D supplementation combined with currently known hypoglycemic regimens may be a comprehensive and individualized treatment in the future.

关 键 词：2型糖尿病 胰岛素抵抗 维生素D 胰岛Β细胞 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]