氧化应激信号转导通路对骨折愈合影响的研究进展  

Research progress on the effect of oxidative stress signal transduction pathways on fracture healing

作　　者：陈镜任 刘刚[1] 朱受权 温海成[2] 李泓成 王希琳[1] Chen Jingren;Liu Gang;Zhu Shouquan;Wen Haicheng;Li Hongcheng;Wang Xilin(Department of Acupuncture and Moxibustion,Guilin Municipal Hospital of Traditional Chinese Medicine,Guangxi Zhuang Autonomous Region,Guilin Hospital Affiliated to Guangxi University of Chinese Medicine,Guilin 541000,China;Guangxi University of Chinese Medicine,Nanning 530000,China)

机构地区：[1]广西壮族自治区桂林市中医医院广西中医药大学附属桂林医院针灸科,桂林541000 [2]广西中医药大学,南宁530000

出　　处：《中国医药》2025年第3期471-475,共5页China Medicine

基　　金：广西壮族自治区自然科学基金(2024GXNSFAA010410);广西中医药大学大学生创新创业训练计划项目(S202310600072);广西中医药大学校级科研项目(2022MS064)。

摘　　要：骨折通常会导致血管断裂和软组织损伤,患处缺血、缺氧以及氧化应激反应。氧化应激过程中,活性氧作为第二信使参与激活信号转导通路。在活性氧的参与下,线粒体氧化应激异常、Kelch样环氧氯丙烷相关蛋白1/核因子E2相关因子2/抗氧化反应元件信号通路、核因子κB信号通路以及沉默交配型信息调节因子2同源蛋白1-叉头框转录因子O信号通路均可以调控成骨细胞、破骨细胞的增殖与凋亡,进而影响骨折愈合的进程。近年来,线粒体功能研究兴起,氧化应激相关信号通路与骨折愈合的相关研究不断取得进展。深入研究线粒体氧化应激以及相关信号转导的靶点与机制可进一步理解骨髓间充质干细胞的成骨分化、成骨细胞活性和破骨细胞凋亡,为临床骨折的治疗提供理论依据。Fractures often result in broken blood vessels and soft tissue damage,ischemia,hypoxia,and oxidative stress.Reactive oxygen species act as second messengers to activate signal transduction pathways during oxidative stress.In the presence of reactive oxygen species,Abnormal mitochondrial oxidative stress,Kelch-like epichlorohydrin related protein 1/nuclear factor E2-related factor 2/antioxidant response element signaling pathway,nuclear factor-κB signaling pathway and silent mating type information regulator 2 homologous protein 1 forkhead box transcription factor O signaling pathway can regulate the proliferation and apoptosis of osteoblasts and osteoclasts.It can affect the process of fracture healing.In recent years,the research on mitochondrial function has been on the rise,and the related research on oxidative stress-related signaling pathways and fracture healing has been progressing.Further study on the targets and mechanisms of mitochondrial oxidative stress and related signal transduction can further understand the osteogenic differentiation,osteoblast activity and osteoclast apoptosis of bone marrow mesenchymal stem cells,and provide theoretical basis for the treatment of clinical fractures.

关 键 词：骨折愈合 氧化应激 信号转导通路 活性氧 

分 类 号：R274.1[医药卫生—中医骨伤科学]