大黄䗪虫丸联合西药治疗下肢动脉硬化闭塞症疗效研究  

Study on application of Dahuang Zhechong pill combined with conventional western medicine in treatment of arteriosclerosis obliterans of lower limbs

作　　者：陈凡平 宁红霞 汪海波 杨晓萌 祁爱风 CHEN Fanping;NING Hongxia;WANG Haibo;YANG Xiaomeng;QI Aifeng(Shijiazhuang Traditional Chinese Medicine Hospital,Shijiazhuang 050051,China)

机构地区：[1]石家庄市中医院,河北石家庄050051

出　　处：《陕西中医》2025年第3期364-367,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2023377)。

摘　　要：目的:探究大黄䗪虫丸联合常规西药治疗下肢动脉硬化闭塞症(ASO)的临床疗效。方法:选择90例ASO患者,按随机数字表法分为两组,各45例。单用药组使用西洛他唑治疗,联合用药组加用大黄䗪虫丸治疗。比较两组患者血管通畅率、皮肤温度感、血清学指标和临床疗效。结果:治疗后,两组血管内径、峰值流速、血流量均提高,且联合用药组峰值流速、血流量提高更显著(P<0.05)。治疗后两组患者皮温均升高,且联合用药组升高更明显(P<0.05)。一氧化氮(NO)和可溶性微纤维相关蛋白4(sMFAP4)在两组治疗后均上升,内皮素-1(ET-1)均下降,且联合用药组各项指标上升及下降均较单独用药组更显著(P<0.05)。两组临床总有效率分别为联合用药组97.78%、单用药组82.22%,组间比较差异有统计学意义(P<0.05)。结论:大黄䗪虫丸联合西洛他唑能够有效促进ASO患者血管畅通,提高皮肤温度,改善血清sMFAP4水平。Objective:To explore clinical effect of Dahuang Zhechong pill combined with conventional western medicine in lower extremity arteriosclerosis obliteration(ASO).Methods:90 ASO patients were divided into 45 control group and 45 observation group by random number table method.The single-drug group were treated with ciloprazole,and the combined drug group were treated with Dahuang Zhechong pill.The vascular patency rate,skin temperature sensation,serological indexes and clinical efficacy of the two groups were compared.Results:After treatment,internal diameter,peak velocity and blood flow of the two groups were increased,and the increases of peak velocity and blood flow were more significant in the combination group(P<0.05).After treatment,the skin temperature of both groups was increased,and the increase was more obvious in the combined treatment group(P<0.05).After treatment,the skin temperature of both groups was increased,and the increase was more obvious in the combined treatment group(P<0.05).Nitric oxide(NO)and soluble microfiber-associated protein 4(sMFAP4)were both increased and endothelin-1(ET-1)were decreased after treatment in both groups,and the increase and decrease of various indexes in the combined treatment group were more significant than those in the single treatment group(P<0.05).The total clinical effective rate of the two groups was 97.78%in the combined drug group and 82.22%in the single drug group,and the clinical effect of the combined drug group was significantly higher(P<0.05).Conclusion:The combination of Dahuang Zhechong pill and cilostazol can effectively promote vascular patency,increase skin temperature,and improve serum sMFAP4 level in ASO patients.

关 键 词：下肢动脉硬化闭塞症 大黄䗪虫丸 西洛他唑 血管通畅率 皮肤温度感 可溶性微纤维相关蛋白4 

分 类 号：R255.7[医药卫生—中医内科学]