健脾益气法治疗结直肠癌研究进展  

Research progress in epigenetic treatment of colorectal cancer by spleen and Qi strengthening method

作　　者：王静[1] 唐泊文 宋囡[1] 李政 WANG Jing;TANG Bowen;SONG Nan;LI Zheng(Liaoning University of Chinese Medicine,Shenyang 110847,China;Cancer Hospital of China Medical University,Shenyang 110042,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁省肿瘤医院,辽宁沈阳110042

出　　处：《陕西中医》2025年第3期420-423,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：辽宁省科技计划项目(2023JH2/101700149);辽宁省自然科学基金计划指导项目(2019-ZD-0584);辽宁中医药大学开放基金资助项目(ZYZX2205)。

摘　　要：脾虚是结直肠癌发生的关键,健脾益气法是结直肠癌的重要治法。该法可防治各时期的结直肠癌,但具体机制尚不明确。既往研究显示,健脾益气法与有关疾病在表观遗传修饰上相关联。本研究以表观遗传作为切入点,探讨益气健脾法的作用机制。结直肠癌通过甲基化、组蛋白修饰等影响疾病发生发展、转移、EMT及耐药。Spleen deficiency was the key to occurrence of colorectal cancer.Method of invigorating spleen and supplementing Qi was an important treatment for colorectal cancer.Clinical experience had proved that invigorating spleen and invigorating Qi could prevent and treat colorectal cancer at various stages,but specific mechanism was still unclear.Took epigenetic inheritance as break through point to explore mechanism of invigorating Qi and invigorating spleen.Invigorating spleen and invigorating Qi had been linked to epigenetic modifications in other diseases.Colorectal cancer affects development,metastasis,EMT and drug resistance through methylation and histone modification.

关 键 词：益气健脾 结直肠癌 表观遗传学 甲基化 组蛋白修饰 非编码RNA 

分 类 号：R273[医药卫生—中西医结合]