绝经综合征患者认知功能障碍的相关影响因素研究  

Influencing Factors Associated with Cognitive Dysfunction in Patients with Menopausal Syndrome

作　　者：赵靖昌 丛超 翟子琪 李盛楠 赵莉[1] 刘慧聪[1] 张玥 宗嬿 陈宜爽 陶敏芳[2] 金富锐[3] 王文君[4] 倪晓蓉 沈明洁[6] 徐莲薇[1] ZHAO Jingchang;CONG Chao;ZHAI Ziqi;LI Shengnan;ZHAO Li;LIU Huicong;ZHANG Yue;ZONG Yan;CHEN Yishaung;TAO Minfang;JIN Furui;WANG Wenjun;NI Xiaorong;SHEN Mingjie;XU Lianwei(Department of Gynecology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China;Shanghai Sixth People′s Hospital,Shanghai 201204,China;International Peace Maternity and Child Health Hospital of China Welfare Institute,Shanghai 200030,China;Obstetrics and Gynecology Hospital Affiliated to Fudan University,Shanghai 200001,China;Shanghai Hospital of Traditional Chinese Medicine,Shanghai 200071,China;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属龙华医院妇科,上海200030 [2]上海市第六人民医院,上海201204 [3]中国福利会国际和平妇幼保健院,上海200030 [4]复旦大学附属妇产科医院,上海200001 [5]上海市中医医院,上海200071 [6]上海中医药大学附属曙光医院,上海201203

出　　处：《世界中医药》2024年第23期3669-3674,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(82174427,82305290)。

摘　　要：目的:探讨绝经综合征(MPS)患者认知功能障碍的发生率及影响因素。方法:采用横断面调查研究方法,收集2021年1月至2022年3月在上海21家医院门诊就诊的MPS患者的基本信息,运用蒙特利尔认知评估量表(MOCA)评估其是否存在认知功能障碍,采用多因素回归分析方法探讨MPS患者认知功能障碍的影响因素,并绘制受试者工作特征曲线(ROC曲线)评估Logistic回归模型的效果。结果:738例MPS患者的认知功能障碍发生率为28.18%。单因素分析结果显示,阅读习惯、职业性质、城市农村、学历、饮食习惯、收入、体质量指数(BMI)、症状初始年龄、每周运动次数、电子产品使用时长、Kupperman评分对MPS患者认知功能障碍有影响(P<0.05);多因素回归分析结果显示,素食为主食、高BMI、较大症状初始年龄、较多的每周运动次数为MPS患者认知功能障碍的独立保护因素,而每日较长的电子产品使用时长、高Kupperman评分是独立危险因素,职业性质、学历、饮食也是独立影响因素。ROC曲线下面积为0.838,提示预测模型良好。结论:MPS患者认知功能障碍的影响因素较多,其中职业性质、学历、饮食习惯、BMI、症状初始年龄、每周运动次数、电子产品使用时长、Kupperman评分等都会对MPS患者的认知功能产生影响。Objective:To explore the incidence and influencing factors of cognitive dysfunction in patients with menopausal syndrome(MPS).Methods:A cross-sectional survey was conducted to collect basic information from MPS patients who visited outpatient clinics in 21 hospitals in Shanghai between January 2021 and March 2022.The Montreal Cognitive Assessment(MOCA)was used to assess cognitive dysfunction.Multivariate regression analysis was applied to explore the influencing factors of cognitive dysfunction in MPS patients,and receiver operating characteristic(ROC)curves were drawn to evaluate the effectiveness of the Logistic regression model.Results:The incidence of cognitive dysfunction in 738 MPS patients was 28.18%.Univariate analysis showed that reading habits,occupational nature,urban vs.rural residence,education level,dietary habits,income,body mass index(BMI),age at symptom onset,weekly exercise frequency,screen time,and Kupperman score were all related to cognitive dysfunction in MPS patients(P<0.05).Multivariate regression analysis revealed that a vegetarian diet,higher BMI,older age at symptom onset,and more frequent weekly exercise were independent protective factors for cognitive dysfunction in MPS patients,while longer daily screen time and higher Kupperman scores were independent risk factors.Occupational nature,education level,and diet were also independent influencing factors.The area under the ROC curve was 0.838,indicating a good predictive model.Conclusion:Cognitive dysfunction in MPS patients is influenced by multiple factors,including occupational nature,education level,dietary habits,BMI,age at symptom onset,weekly exercise frequency,screen time,and Kupperman score.These factors significantly affect cognitive function in MPS patients.

关 键 词：绝经综合征 认知功能障碍 蒙特利尔认知评估量表 影响因素 多中心研究 横断面研究 多因素LOGISTIC回归分析 

分 类 号：R271.1[医药卫生—中医妇科学]